Systemic lupus erythematosus is a chronic multisystem disorder characterized by the presence of distinctive antinuclear antibodies. In a subset of these patients designated as ‘anti-nuclear antibody-negative systemic lupus erythematosus’ these antibodies are absent. We report a young girl with antinuclear antibody-negative systemic lupus erythematosus and discuss its characteristics and differences with antinuclear antibody-positive systemic lupus erythematosus. Key words Systemic lupus erythematosus - Antinuclear antibodies - Clinical features
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