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首页> 外文期刊>Indian Journal of Pediatrics >Clinical profile and outcome of acute respiratory failure
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Clinical profile and outcome of acute respiratory failure

机译：急性呼吸衰竭的临床表现和预后

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Objective : To examine the etiological factors, clinical features, treatment modalities and outcome of acute respiratory failure in children.Methods : This hospital-based prospective observational study was conducted over 15 months. Fifty children with acute respiratory failure, diagnosed by serial arterial blood gas analysis, were consecutively enrolled. Ventilation therapy was initiated when the FiO2 requirement went above 0.6.Results : Pulmonary diseases accounted for majority (68%) of cases, followed by nervous system (12%); and cardiovascular and skeletal muscle system diseases (10%, each). Bronchopneumonia was the commonest cause of acute respiratory failure (11 cases). The majority of cases were in the age group 1 month to < 1 year (26 cases). The commonest signs were altered depth and pattern of respiration (100%), chest wall retractions (88%), flaring of alae nasae (88%), tachypnea (84%), tachycardia (82%), and irritability (64%). Cyanosis was noticed in only 26 (52%) cases. Thirty-six (72%) children required ventilation therapy. The overall mortality was 58%. The mortality was high (55.9% to 66.7%), irrespective of the primary system involved. Significantly higher mortality was associated with co-existent malnutrition (p<0.001), Type I failure (p=0.039) and ventilation therapy (p<0.0001).Conclusion : Acute respiratory failure has varied etiology and clinical manifestations, and a high mortality. Its outcome is independent of age of the child and the primary system involved. Malnutrition and Type I failure are factors associated with a poor outcome. Key words Acute respiratory failure - Arterial blood gas analysis - Child - Developing countries - India
机译：目的：探讨儿童急性呼吸衰竭的病因，临床特征，治疗方式和预后。方法：该医院为基础的前瞻性观察研究进行了15个月。通过连续动脉血气分析诊断为五十例患有急性呼吸衰竭的儿童。当FiO 2 需求超过0.6时开始进行通气治疗。结果：肺部疾病占大多数（68％），其次是神经系统（12％）；以及心血管和骨骼肌系统疾病（各占10％）。支气管肺炎是急性呼吸衰竭的最常见原因（11例）。大多数病例处于1个月至<1年的年龄组（26例）。最常见的体征是呼吸深度和模式改变（100％），胸壁回缩（88％），阿拉斯鼻翼张开（88％），呼吸急促（84％），心动过速（82％）和易怒（64％） 。仅在26（52％）例中发现了紫yan。三十六（72％）名儿童需要通气治疗。总死亡率为58％。不论所涉及的主要系统如何，死亡率都很高（55.9％至66.7％）。并存的营养不良（p <0.001），I型衰竭（p = 0.039）和通气疗法（p <0.0001）与死亡率显着相关。结论：急性呼吸衰竭的病因和临床表现各异，死亡率高。其结果与孩子的年龄和所涉及的主要系统无关。营养不良和I型衰竭是与不良预后相关的因素。关键词急性呼吸衰竭-动脉血气分析-儿童-发展中国家-印度

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