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首页> 外文期刊>Infectious Disorders - Drug Targets >Stroke Bugs: Current and Emerging Concepts Relevant to Infection in Cerebrovascular Disease
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Stroke Bugs: Current and Emerging Concepts Relevant to Infection in Cerebrovascular Disease

机译：中风病：与脑血管疾病感染相关的最新概念

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摘要

In this fascinating special topic issue, contributors from various centres in the UK, Europe and the US have reviewed a nrange of subjects on the theme of infection and stroke. What is perhaps most surprising is that relatively little attention has been ndevoted to such a clinically important topic until very recently. The relationships between infection and stroke are wide nranging, as illustrated by the diversity of topics covered in this collection. Infection occurring before and after stroke has huge nclinical implications, and a better knowledge of mechanisms in paediatric as well as adult populations - and in other specific npopulations such as individuals with HIV infection - is likely to be increasingly important from a global perspective. Relatively nrecent developments also include the increasing recognition of VZV vasculopathy in stroke, and the concept of aggregate nchronic infectious burden in stroke risk. In addition to well established risk factors for infection poststroke, evidence for npoststroke immunodepression is increasing. Models of infection before and after stroke should facilitate the investigation of nnew targets. From a clinical viewpoint there is increasing recognition that greater account needs to be taken of infection when nconsidering both established and novel acute stroke treatments. The swine flu pandemic has of course also brought influenza ninto sharp focus and there can be little doubt about the importance of vaccination uptake in appropriate groups.
机译：在这个引人入胜的专题文章中，来自英国，欧洲和美国不同中心的撰稿人对感染和中风这一主题进行了广泛讨论。也许最令人惊讶的是，直到最近，对这种临床上重要的话题的关注还很少。感染与中风之间的关系范围很广，如本系列所涵盖的主题之多所说明。从全球的角度来看，在中风之前和之后发生的感染具有巨大的临床意义，对儿科和成人人群以及在其他特定人群（如感染HIV的人群）中机制的更好了解可能越来越重要。相对较新的进展还包括对中风中VZV血管病的日益认识，以及中风风险中总慢性传染病负担的概念。除了已确定的中风后感染的危险因素外，中风后免疫抑制的证据也在增加。中风前后的感染模型应有助于研究新的靶标。从临床观点出发，越来越多的认识是，在考虑既定的和新颖的急性中风治疗时都需要更多地考虑感染。猪流感大流行当然也使流感成为人们关注的焦点，毫无疑问，在适当的人群中接种疫苗的重要性。

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  • 来源
    《Infectious Disorders - Drug Targets》 |2010年第2期|p.65-66|共2页
  • 作者

    Hedley CA Emsley Angel Chamorro;

  • 作者单位

    Consultant Neurologist, Department of Neurology, Royal Preston Hospital, Sharoe Green Lane, Preston PR2 9HT & Honorary Lecturer, University of Liverpool, UK;

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