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Giardiasis, Drug Resistance, and New Target Discovery

机译:贾第鞭毛虫病,耐药性和新靶标发现

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摘要

Giardiasis is a worldwide parasitic disease caused by the protozoan Giardia lamblia in humans and other animals, especially live stocks. Here, we briefly review the current state of therapeutic availability for giardiasis, including chemical drugs and vaccines, and the dilemma in the prevention and treatment of this disease, including the emergence of drug resistance and the shortage of vaccine (especially for humans). Future efforts and progress in controlling giardiasis are expected in three aspects: clarification of the drug resistance mechanisms, development of efficient vaccines, and identification of more targets for new drugs and vaccines.
机译:贾第鞭毛虫病是一种全球寄生虫病,是由原生动物贾第鞭毛虫兰比亚在人类和其他动物(尤其是牲畜)中引起的。在这里,我们简要回顾了贾第鞭毛虫病(包括化学药物和疫苗)的治疗可用状态,以及该疾病的预防和治疗困境,包括耐药性的出现和疫苗的短缺(特别是对人类)。预计在控制贾第鞭毛虫病方面将做出进一步努力,并在三个方面取得进展:阐明耐药机制,开发有效疫苗以及确定更多新药和疫苗靶标。

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