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Editorial [Hot Topic: Redox Status in the Pathophysiology of Inflammation and Therapeutic Targets (Executive Editor: Mena Soory)]

机译：社论[热门话题：炎症和治疗靶标的病理生理学中的氧化还原状态（执行编辑：Mena Soory）]

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I was able to compile this work due to an enthusiastic response from experts in the field. It encompasses the pathophysiology of inflammation relevant to physiological states, infections, autoimmune and metabolic diseases.nnThis supplement demonstrates the increasing importance of redox-sensitive mechanisms during physiological function, inflammatory pathology, sepsis and carcinogenesis. The relevance of anti-oxidant defences and therapeutic applications, including current and future potential for nanotechnology is highlighted. It could play a strategic role in the adjunctive therapy of protracted chronic diseases by avoiding side effects of prescriptive medication.nnThere are several advances in therapeutic utilisation of antioxidants produced by the host in response to pathophysiological states and those of dietary origin for their effective management. The diverse conditions addressed project the importance of oxidative stress during inflammation and effective methods of intervention which could benefit co-existing diseases with a similar progression.nnThe ubiquitous nature of inflammation as a component of diverse acute and chronic pathological states underscores the importance of effective therapeutic targeting; often made difficult by complex interactions between receptors, therapeutic agents and host derived products. Streamlined application of these concepts for effective therapeutic targeting and focused delivery is a challenge for the future.
机译：由于该领域专家的热情响应，我能够编写这份工作。它涵盖了与生理状态，感染，自身免疫性疾病和代谢性疾病相关的炎症的病理生理学。nn此补充说明氧化还原敏感机制在生​​理功能，炎症病理，败血症和致癌过程中的重要性日益提高。强调了抗氧化防御和治疗应用的相关性，包括当前和未来纳米技术的潜力。通过避免处方药的副作用，它可以在旷日持久的慢性疾病的辅助治疗中发挥战略作用。nn宿主对病理生理状态和饮食来源的抗氧化剂的有效利用在抗氧化剂的治疗利用方面取得了一些进展。所解决的各种状况预测了炎症过程中氧化应激的重要性以及可以使进展类似的并存疾病受益的有效干预方法。炎症作为各种急性和慢性病理状态的组成部分，其普遍存在强调了有效治疗的重要性。定位；通常由于受体，治疗剂和宿主衍生产物之间的复杂相互作用而变得困难。这些概念的简化应用以实现有效的治疗目标和集中交付是未来的挑战。

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  • 来源
    《Infectious Disorders - Drug Targets》 |2009年第4期|p.375-375|共1页
  • 作者

    Mena Soory;

  • 作者单位

    Infectious Disorders-Drug Targets Periodontology King's College London Dental Institute United Kingdom.;

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