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首页> 外文期刊>Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) >Relationship Between Non-Genomic Actions of Estrogens and Insulin Resistace
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Relationship Between Non-Genomic Actions of Estrogens and Insulin Resistace

机译：雌激素的非基因作用与胰岛素抵抗之间的关系

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Numerous experimental and clinical data show that the physiological actions of insulin and sexual steroids interact in target tissues for these hormones. In the other hand, sexual steroids has effects on peripheral tissues, and since the skeletal muscle is the main responsible for peripheral glucose uptake, it would be possible that the sexual steroids induce directly in the muscle a decrease of the sensibility of this tissue to insulin action. Some of the biological actions of the estrogens are too fast like to be compatible with this classical mechanism of action, and this mechanism has been called not classical, non-genomic or rapid actions of the estrogens. Moreover, some experiments have shown that low concentrations of estradiol, induce an increase in the rate of IRS-1 phosphorylation, promotes the association between IRS-1 and the subunit of PI3-k, p85α, causes a decrease in the rate of IRS-1 serine phosphorylation and increases the rate of Akt phosphorylation. Therefore, the evidences suggest the existence of a narrow interrelation between the estrogens and insulin sensitivity, but relatively few studies have tried to resolve the molecular base of this relation in insulindependent tissues. The resolution of these unknown questions would be able to have a great long-term therapeutic repercussion. In this sense, we should not forget that insulin resistance is the underlying cause of several associated pathologies to the female aging, as Type 2 diabetes, cardio-circulatory pathology or neurodegenerative disease
机译：许多实验和临床数据表明，胰岛素和性类固醇的生理作用在这些激素的靶组织中相互作用。另一方面，性类固醇对周围组织有影响，由于骨骼肌是引起外周葡萄糖摄取的主要因素，因此性类固醇可能直接在肌肉中诱导该组织对胰岛素的敏感性降低行动。雌激素的某些生物学作用太快而不能与这种经典的作用机理相容，因此这种机理被称为非经典的，非基因组的或快速的雌激素作用。此外，一些实验表明，低浓度的雌二醇可导致IRS-1磷酸化速率增加，促进IRS-1与PI3-k亚基p85α之间的缔合，从而导致IRS-P速率降低。 1丝氨酸磷酸化并增加Akt磷酸化的速率。因此，有证据表明，雌激素和胰岛素敏感性之间存在狭窄的相互关系，但是相对较少的研究试图在胰岛素依赖性组织中解决这种关系的分子基础。这些未知问题的解决将能够产生长期的治疗效果。从这个意义上讲，我们不应忘记胰岛素抵抗是导致女性衰老的几种相关病理的根本原因，例如2型糖尿病，心血管循环病理或神经退行性疾病

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