...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Inflammation >Effects of Dexamethasone and Salvia miltiorrhizae on the Small Intestine and Immune Organs of Rats with Severe Acute Pancreatitis
【24h】

Effects of Dexamethasone and Salvia miltiorrhizae on the Small Intestine and Immune Organs of Rats with Severe Acute Pancreatitis

机译：地塞米松和丹参对重症急性胰腺炎大鼠小肠和免疫器官的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To observe the protecting effects and mechanisms of Dexamethasone and Salviae miltiorrhizae on intestinal mucosa and immune organs (spleen, thymus and lymph node) in rats with severe acute pancreatitis (SAP). The rats were randomly divided into sham-operated, model control, Dexamethasone treated group and Salviae miltiorrhizae treated group. At 3, 6 and 12 h after operation, the mortality rate, pathological changes of intestinal mucosa and immune organs as well as the contents of serum PAF, IL-1β and sIL-2R were observed, respectively. The mortality rate and the contents of PAF (at 3 and 6 h), IL-1β (at all time points) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 h) in Dexamethasone treated group were significantly lower than those in model contrlo groups (P < 0.05). The contents of PAF (at 3 and 12 h), IL-1β (at 6 and 12 h) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 and 12 h) in Salviae miltiorrhizae treated group were markedly lower than those in model contrlo groups (P < 0.05). Since both Dexamethasone and Salvia miltiorrhizae can reduce the contents of serum PAF, sIL-2R and IL-1β, mitigate the pathological changes in the small intestine, spleen and thymus and reduce the mortality rate of SAP rats, they show good therapeutic effects on SAP rats.
机译：观察地塞米松和丹参对重症急性胰腺炎（SAP）大鼠肠道粘膜和免疫器官（脾，胸腺和淋巴结）的保护作用和机制。将大鼠随机分为假手术组，模型对照组，地塞米松治疗组和丹参治疗组。术后3、6、12 h分别观察死亡率，肠黏膜和免疫器官的病理变化以及血清PAF，IL-1β和sIL-2R的含量。死亡率和PAF含量（在3和6小时），IL-1β（在所有时间点）和sIL-2R（在3和6小时）以及胸腺的病理评分（在所有时间点）地塞米松治疗组的脾脏和脾脏（3 h）显着低于模型对照组（P <0.05）。 PAF（在3和12小时），IL-1β（在6和12小时）和sIL-2R（在3和6小时）的含量以及胸腺（在所有时间点）和脾脏的病理评分（丹参治疗组在3、12 h）明显低于模型对照组（P <0.05）。由于地塞米松和丹参均可以降低血清PAF，sIL-2R和IL-1β的含量，减轻小肠，脾脏和胸腺的病理变化，并降低SAP大鼠的死亡率，因此它们对SAP具有良好的治疗作用。大鼠。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号