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首页> 外文期刊>Inflammation >Walnut Extract Inhibits LPS-induced Activation of Bv-2 Microglia via Internalization of TLR4: Possible Involvement of Phospholipase D2
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Walnut Extract Inhibits LPS-induced Activation of Bv-2 Microglia via Internalization of TLR4: Possible Involvement of Phospholipase D2

机译：核桃提取物通过TLR4的内在作用抑制LPS诱导的Bv-2小胶质细胞活化：磷脂酶D2的可能参与

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摘要

Walnuts are a rich source of essential fatty acids, including the polyunsaturated fatty acids alpha-linolenic acid and linoleic acid. Essential fatty acids have been shown to modulate a number of cellular processes in the brain, including the activation state of microglia. Microglial activation can result in the generation of cytotoxic intermediates and is associated with a variety of age-related and neurodegenerative conditions. In vitro, microglial activation can be induced with the bacterial cell wall component lipopolysaccharide (LPS). In the present study, we generated a methanolic extract of English walnuts (Juglans regia) and examined the effects of walnut extract exposure on LPS-induced activation in BV-2 microglial cells. When cells were treated with walnut extract prior to LPS stimulation, production of nitric oxide and expression of inducible nitric oxide synthase were attenuated. Walnut extract also induced a decrease in tumor necrosis-alpha (TNFα) production. We further found that walnut extract induced internalization of the LPS receptor, toll-like receptor 4, and that the anti-inflammatory effects of walnut were dependent on functional activation of phospholipase D2. These studies represent the first to describe the anti-inflammatory effects of walnuts in microglia, which could lead to nutritional interventions in the prevention and treatment of neurodegeneration.
机译：核桃是必需脂肪酸的丰富来源，包括多不饱和脂肪酸α-亚麻酸和亚油酸。必需脂肪酸已显示出可调节大脑中许多细胞过程，包括小胶质细胞的活化状态。小胶质细胞活化可导致细胞毒性中间体的产生，并与多种年龄相关和神经退行性疾病有关。在体外，可以用细菌细胞壁成分脂多糖（LPS）诱导小胶质细胞活化。在本研究中，我们生成了英国核桃仁（Juglans regia）的甲醇提取物，并研究了核桃提取物暴露对LPS诱导的BV-2小胶质细胞活化的影响。当在LPS刺激之前用核桃提取物处理细胞时，一氧化氮的产生和诱导型一氧化氮合酶的表达减弱。核桃提取物还引起肿瘤坏死-α（TNFα）产生的减少。我们进一步发现核桃提取物诱导了LPS受体，toll​​-like受体4的内在化，并且核桃的抗炎作用取决于磷脂酶D2的功能激活。这些研究代表了第一个描述核桃在小胶质细胞中的抗炎作用，这可能导致预防和治疗神经变性的营养干预。

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