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首页> 外文期刊>Inflammation >Influence of Baicalin and Octreotide on NF-κB and P-Selectin Expression in Liver and Kidney of Rats with Severe Acute Pancreatitis
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Influence of Baicalin and Octreotide on NF-κB and P-Selectin Expression in Liver and Kidney of Rats with Severe Acute Pancreatitis

机译：黄ical苷和奥曲肽对重症急性胰腺炎大鼠肝肾中NF-κB和P-选择蛋白表达的影响

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摘要

To observe the influence of Baicalin and Octreotide on liver and kidney of rats with severe acute pancreatitis (SAP) and discuss the related mechanism. SAP rats were randomly divided into model control, Baicalin treated and Octreotide treated group (n = 45). The same number of normal rats were included in sham-operated group (n = 45). In all groups, the mortality rate, pathological changes as well as expression levels of NF-κB p65 and P-selectin protein in liver and kidney were observed at 3, 6 and 12 h after operation. The survival rate of treated group was 100% at 12 h significantly higher than that of model control group (P < 0.05). The pathological changes of liver and kidney in treated groups were alleviated to different degrees, the NF-κB protein expression levels and pathological severity scores in liver and kidney of treated groups were significantly lower than those of model control group (P < 0.05 or P < 0.001). The hepatic P-selectin protein expression level in Baicalin treated group was significantly lower than that of model control group at 3 h (P < 0.01), and renal P-selectin expression level in Baicalin treated group at 3 and 6 h were significantly lower than those of model control group and Octreotide treated group (P < 0.01). (1) Early treatment with Baicalin or Octreotide have obvious protecting effects on liver and kidney injuries in SAP with their mechanisms associated to inhibiting NF-κB and P-selectin expression of liver and kidney. (2) Comparing the pharmacologic effects of Octreotide and Baicalin, we believe Baicalin as a new drug with its protecting effects on liver and kidney of SAP rats similar to Octreotide is worth further studying. (3) The advantages of tissue microarrays in pathological examination include time and energy saving and highly efficient. But the restriction of small diameter weakens the representation of tissues to various extents, which may lead to the deviation of analysis.
机译：观察黄ical苷和奥曲肽对重症急性胰腺炎（SAP）大鼠肝肾的影响，并探讨其相关机制。将SAP大鼠随机分为模型对照组，黄ical苷治疗组和奥曲肽治疗组（n = 45）。假手术组包括相同数量的正常大鼠（n = 45）。各组在术后3、6、12 h观察肝，肾的死亡率，病理变化以及NF-κBp65和P-选择素蛋白的表达水平。治疗组12 h生存率100％，明显高于模型对照组（P <0.05）。治疗组肝脏和肾脏的病理变化有不同程度的缓解，治疗组肝肾中NF-κB蛋白表达水平和病理严重程度评分均明显低于模型对照组（P <0.05或P < 0.001）。黄ical苷治疗组在3 h时肝P-选择素蛋白表达水平显着低于模型对照组（P <0.01），黄group苷治疗组在3和6 h时肝P-selectin表达水平显着低于模型对照组。模型对照组和奥曲肽治疗组的差异有统计学意义（P <0.01）。 （1）黄ical苷或奥曲肽的早期治疗对SAP的肝肾损伤具有明显的保护作用，其机制可能与抑制肝肾中NF-κB和P-选择素的表达有关。 （2）通过比较奥曲肽和黄ical苷的药理作用，我们认为黄ical苷作为一种新药具有与奥曲肽相似的对SAP大鼠肝肾的保护作用，值得进一步研究。 （3）组织芯片在病理检查中的优势包括省时，节能，高效。但是小直径的限制会在不同程度上削弱组织的表示，这可能导致分析的偏差。

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