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首页> 外文期刊>Inflammation >Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats
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Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats

机译：α-硫辛酸可改善乙酸诱导的大鼠胃溃疡的愈合

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To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic score, elevated DNA fragmentation and chemiluminescence levels of the saline-treated ulcer groups were all reduced by ALA treatment. Likewise, ALA treatment inhibited chemiluminescence levels in both early and late ulcer groups. Marked reduction in glutathione levels of the saline-treated early ulcer group was reversed by ALA treatment, while ALA treatment was effective in depressing gastric myeloperoxidase activity in the late ulcer group. In conclusion, ALA treatment shows protective role in the healing of acetic acid-induced gastric injury in rats via the suppression of neutrophil accumulation, preservation of endogenous glutathione, inhibition of reactive oxidant generation and apoptosis.
机译：为了评估ALA治疗在乙酸诱发的胃溃疡愈合中的作用，在诱发溃疡之前先给大鼠服用ALA（35 mg / kg /天）或生理盐水3天，然后每天两次连续治疗2天（早期）或10天（后期），直到他们被斩首。盐水治疗的溃疡组的胃溃疡指数，显微评分，DNA片段升高和化学发光水平均通过ALA治疗降低。同样，ALA治疗在早期和晚期溃疡组中均抑制了化学发光水平。盐水治疗的早期溃疡组的谷胱甘肽水平的显着降低通过ALA治疗得以逆转，而ALA治疗在晚期溃疡组中有效降低了胃髓过氧化物酶活性。总之，ALA治疗通过抑制中性粒细胞积累，内源性谷胱甘肽的保存，抑制活性氧化剂的产生和凋亡，在乙酸引起的大鼠胃损伤的愈合中显示出保护作用。

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