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首页> 外文期刊>Inflammation >Repeated Systemic Escherichia coli Infection Enhances Anti-oxidant Response in Hypercholesterolemic Mice Inducing Cardiovascular Inflammation
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Repeated Systemic Escherichia coli Infection Enhances Anti-oxidant Response in Hypercholesterolemic Mice Inducing Cardiovascular Inflammation

机译：反复的全身性大肠杆菌感染增强了高胆固醇血症小鼠诱导心血管炎症的抗氧化反应。

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It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to development of oxidative stress that may affect the development and progression of inflammatory CVD. Swiss albino mice (4 weeks old) were randomly assigned to high cholesterol diet (HCD) or normal laboratory diet (NLD) groups. At 10 weeks of age, mice were inoculated intravenously with E. coli or vehicle for 24 weeks. Serum cholesterol, low density lipoprotein, C reactive protein levels, blood glucose level and selective antioxidant enzymes throughout the systemic infection period in murine aorta, heart and liver during hypercholesterolemia, were examined. Serum cholesterol levels were elevated in HCD-fed mice, compared to NLD. The blood colony forming units (CFU) of E. coli suggested persistence of systemic infection. The antioxidant enzyme levels were elevated in E. coli infected groups as compared to controls. The myeloperoxidase content of aortic tissue was significantly higher in all groups infected with E. coli. Our study suggests that during hypercholesterolemia, repeated systemic E. coli infection induces an endogenous antioxidant response that serves to modulate vascular inflammation leading to cardiovascular diseases.
机译：众所周知，高胆固醇和饱和脂肪酸的饮食可显着提高血浆胆固醇水平，并增加罹患心血管疾病的风险。我们假设重复的全身性大肠杆菌（E. coli）与高胆固醇血症一起导致氧化应激的发展，这种氧化应激可能会影响炎症性CVD的发展和进程。将瑞士白化病小鼠（4周龄）随机分为高胆固醇饮食（HCD）或正常实验室饮食（NLD）组。在10周龄时，给小鼠静脉内接种大肠杆菌或溶媒24周。在高胆固醇血症期间，在小鼠主动脉，心脏和肝脏的整个系统感染期间，检查了血清胆固醇，低密度脂蛋白，C反应蛋白水平，血糖水平和选择性抗氧化酶。与NLD相比，HCD喂养的小鼠血清胆固醇水平升高。大肠杆菌的血菌落形成单位（CFU）表明持续存在全身感染。与对照组相比，大肠杆菌感染组的抗氧化酶水平升高。在所有感染大肠杆菌的组中，主动脉组织的髓过氧化物酶含量均显着较高。我们的研究表明，在高胆固醇血症期间，反复的全身性大肠杆菌感染会诱导内源性抗氧化反应，从而调节血管炎症，从而导致心血管疾病。

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