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首页> 外文期刊>Inflammation >Fish Oil-Supplemented Parenteral Nutrition in Severe Acute Pancreatitis Patients and Effects on Immune Function and Infectious Risk: A Randomized Controlled Trial
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Fish Oil-Supplemented Parenteral Nutrition in Severe Acute Pancreatitis Patients and Effects on Immune Function and Infectious Risk: A Randomized Controlled Trial

机译：重症急性胰腺炎患者鱼油补充胃肠外营养及其对免疫功能和感染风险的影响：一项随机对照试验

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The human leukocyte antigen (HLA)-DR expression on monocytes and plasma Interleukin (IL)-10 levels are key indicators of immune response during the acute phase of severe acute pancreatitis (SAP). We designed a pilot study to investigate whether ω−3 fatty acids (FAs) supplemented parenteral nutrition (PN) could improve immune response in SAP patients. Fifty-six SAP patients were enrolled (28 patients in each group) and received isocaloric and isonitrogenous parenteral nutrition, providing 1.0 g/kg/day standard soybean-oil based fat (ω−6 FAs group) or 0.8 g/kg/day soybean oil +0.2 g/kg/day ω−3 FAs based fat (ω−3 FAs group). IL-10, HLA-DR and the ratio of CD4+ to CD8+ were determined before PN treatment and on day 6 after starting PN. The infection and surgery rates were recorded until hospital discharge. A significant IL-10 increase was associated with the administration of ω−3 FAs (p = 0.04, vs ω−6 FAs group). Monocyte HLA-DR expression improved in both groups after 5 days of PN treatment. This increase was significantly higher in the ω−3 FAs group compared to ω−6 FAs (p = 0.01). There was no significant difference of CD4+/CD8+, infection and surgery rates between the two groups. In conclusion, ω−3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. A larger trial is required to see whether ω−3 FAs supplemented PN treatment in SAP patients would result in better clinical outcomes than ω−6 FAs.
机译：单核细胞上人白细胞抗原（HLA）-DR的表达和血浆白细胞介素（IL）-10的水平是严重急性胰腺炎（SAP）急性期免疫反应的关键指标。我们设计了一项初步研究，以研究补充ω-3脂肪酸（FAs）的肠胃外营养（PN）能否改善SAP患者的免疫反应。纳入56位SAP患者（每组28位患者），接受等热量和等氮的肠胃外营养，提供1.0 g / kg /天的标准大豆油基脂肪（ω-6FAs组）或0.8 g / kg /天的大豆油+0.2 g / kg / dayω-3FAs基脂肪（ω-3FAs组）。在PN治疗前和开始PN后第6天测定IL-10，HLA-DR以及CD4 + 与CD8 + 的比率。记录感染和手术率，直到出院为止。 IL-10的显着增加与ω-3FA的给药有关（p = 0.04，而ω-6FAs组）。 PN治疗5天后，两组单核细胞HLA-DR表达均改善。与ω-6FAs相比，ω-3FAs组的这种增加明显更高（p = 0.01）。两组间CD4 + / CD8 + ，感染和手术率无明显差异。总之，补充ω-3FAs PN可以提高SAP患者的IL-10水平和HLA-DR表达。需要更大的试验来观察在SAP患者中用ω-3FAs补充PN治疗是否会比ω-6FAs产生更好的临床结果。

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