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Composite Materials Based on Polyvinylpyrrolidone and Calcium Phosphates for Medicine

机译:基于聚乙烯吡咯烷酮和药物磷酸钙的复合材料

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摘要

Mineral-polymer composites based on PVP and hydroxyapatite (HA) are obtained by in situ deposition in solutions of polyvinylpyrrolidone (PVP). The composites are presented in the form of films of hydrogels. During the in situ formation of HA, according to TEM data, round particles up to 10 nm in size are formed. For HA particles, the CSR values ​​are close to the size of crystals obtained from the TEM data, and for the PVP–HA composites, the particle size obtained from the TEM data significantly exceeds the CSR value. The swelling of the obtained films is studied by the gravimetric method: the swelling curve of the mineral-polymer film containing 1.96% HA has a form characteristic of the swelling of hydrogels. Biological studies of polymers and composites of polymers with HA deposited in situ have shown that by-products of the HA formation reaction have a negative effect on cell viability. However, the obtained materials are promising for use as membranes in osteoplastic surgery.
机译:基于PVP和羟基磷灰石(HA)的矿物 - 聚合物复合材料通过在聚乙烯吡咯烷酮(PVP)的溶液中原位沉积获得。 复合材料以水凝胶的薄膜形式提出。 在原位形成HA的情况下,根据TEM数据,形成高达10nm的圆形粒子。 对于HA粒子,CSR值接近于从TEM数据获得的晶体的尺寸,并且对于PVP-HA复合材料,从TEM数据获得的粒度显着超过CSR值。 通过重量法研究所得薄膜的溶胀:含有1.96%HA的矿物聚合物膜的溶胀曲线具有水凝胶溶胀的形式特征。 用原位沉积的HA与HA的聚合物和复合材料的生物学研究表明,HA形成反应的副产物对细胞活力具有负面影响。 然而,所获得的材料是有前途的,用作骨塑性手术中的膜。

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