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首页> 外文期刊>International journal of circuit theory and applications >A low-power digital IC emulating intracellular calcium dynamics
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A low-power digital IC emulating intracellular calcium dynamics

机译：一种模拟细胞内钙动力学的低功耗数字IC

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摘要

Low power/area cytomorphic chips may be interfaced and ultimately implanted in the human body for cell-sensing and cell-control applications of the future. In such electronic platforms, it is crucial to accurately mimic the biological timescales and operate in real time. This paper proposes a methodology where slow nonlinear dynamical systems describing the behaviour of naturally encountered biological systems can be efficiently realised in hardware. To this end, as a case study, a low power and efficient digital Application-Specific Integrated Circuit capable of emulating slow intracellular calcium dynamics with timescales reaching to seconds has been fabricated in the commercially available AMS 0.35m technology and compared with its analog counterpart. The fabricated chip occupies an area of 1.5mm(2) (excluding the area of the pads) and consumes 18.93nW for each calcium unit from a power supply of 3.3V. The presented cytomimetic topology follows closely the behaviour of its biological counterpart, exhibiting similar time-domain calcium ions dynamics. Results show that the implemented design has the potential to speed up large-scale simulations of slow intracellular dynamics by sharing cellular units in real time.
机译：低功率/面积细胞形态芯片可以被连接并最终植入人体中，以用于未来的细胞传感和细胞控制应用。在此类电子平台中，准确模拟生物时间尺度并实时运行至关重要。本文提出了一种方法，可以用硬件有效地实现描述自然遇到的生物系统行为的慢速非线性动力学系统。为此，作为一个案例研究，已经在市售的AMS 0.35m技术中制造了一种低功耗，高效率的数字专用集成电路，该集成电路能够模拟缓慢的细胞内钙动力学，时标达到数秒，并与模拟同类产品进行了比较。制成的芯片占地1.5mm（2）（不包括焊盘的面积），并且通过3.3V电源为每个钙单元消耗18.93nW。提出的拟模拟物拓扑结构密切遵循其生物学对应物的行为，表现出相似的时域钙离子动力学。结果表明，通过实时共享细胞单元，所实施的设计具有加速慢细胞内动力学的大规模仿真的潜力。

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