Progesterone diffusion through snake skin as a human model membrane

Carla Tagliaferri; Marianna Gallo; Vitale Stanzione; Roberto Nigro

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Progesterone diffusion through snake skin as a human model membrane

机译：孕酮通过蛇皮作为人体模型的膜扩散

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Thanks to its physical and chemical structure, shed snake skin can be used as a model membrane for human skin in in vitro drug delivery experiments. The progesterone mass transfer through Bitis gabonica skin has been studied using a suitable diffusion glass cell. A lag time of 5.7 hours, representative the unsteady diffusion regime, has been observed. After this lag time, the system reaches the steady-state condition during which the diffusion coefficient and the partition coefficient of progesterone in the system have been calculated by the integration of Fick's laws.

机译：由于其物理和化学结构，脱落的蛇皮可用作体外药物传递实验中人体皮肤的模型膜。已经使用合适的扩散玻璃池研究了通过冈比亚牛肝菌皮肤的孕酮传质。观察到5.7小时的滞后时间，代表了不稳定的扩散状态。在此滞后时间之后，系统达到稳态状态，在此期间，已通过Fick定律的积分计算了系统中孕酮的扩散系数和分配系数。

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来源
《International journal of design engineering》 |2011年第2期|p.186-196|共11页
作者
Carla Tagliaferri; Marianna Gallo; Vitale Stanzione; Roberto Nigro;
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作者单位

Department of Chemical Engineering, Universita degli studi di Napoli Federico II, Facolta di Ingegneria, Piazzale Tecchio, 80 Napoli, Italy;

Department of Chemical Engineering, Universita degli studi di Napoli Federico II, Facolta di Ingegneria, Piazzale Tecchio, 80 Napoli, Italy;

Department of Chemical Engineering, Universita degli studi di Napoli Federico II, Facolta di Ingegneria, Piazzale Tecchio, 80 Napoli, Italy;

Department of Chemical Engineering, Universita degli studi di Napoli Federico II, Facolta di Ingegneria, Piazzale Tecchio, 80 Napoli, Italy;

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正文语种 eng
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关键词
progesterone; snake skin; model membrane; diffusion coefficient; partition coefficient;

机译：黄体酮蛇皮;模型膜扩散系数分配系数;

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专利

1. Thermal analysis of a model bio-membrane Human and snake skins [J] . Cheila G. Mothé, Michelle G. Mothé, Alan T. Riga, Journal of Thermal Analysis and Calorimetry . 2011,第3期

机译：模型人膜和蛇皮生物膜的热分析
2. Thermal analysis of a model bio-membrane: Human and snake skins [J] . Mothé C.G., Mothé M.G., Riga A.T., Journal of thermal analysis and calorimetry . 2011,第3期

机译：模型生物膜的热分析：人和蛇皮
3. Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the Uterine Cervix [J] . Natalia Smaglyukova, Elise Thoresen Sletten, Anne ?rbo, Data in Brief . 2020,第3期

机译：关于核孕酮受体（NPR），膜孕酮受体（MPR）和孕酮受体膜组分（PGRMC）的数据来自人子宫子宫子宫内膜组织和子宫子宫颈的癌细胞
4. THERMAL PROPERTIES OF A MODEL BIO-POLYMER SKIN: SHEDDED SNAKE SKINS [C] . Alan T. Riga, Cheila G. Mothé, Tom R. Martin, Proceedings of the 31st annual conference of the North American Thermal Analysis Society(NATAS) . 2003

机译：模型生物聚合物皮肤的热性质：蛇皮
5. Membrane and nuclear progesterone receptors activate tumor suppressive signaling mechanisms in cell line models of human ovarian cancer . [D] . Charles, Nathan Jon. 2010

机译：膜和核孕激素受体激活人类卵巢癌细胞模型中的抑癌信号机制。
6. Data on RT-qPCR assay of nuclear progesterone receptors (nPR) membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the Uterine Cervix [O] . Natalia Smaglyukova, Elise Thoresen Sletten, Anne Ørbo, 2020

机译：关于核孕酮受体（NPR）膜孕酮受体（MPR）和孕酮受体膜组分（PGRMC）的数据来自人子宫子宫子宫内膜组织和子宫子宫颈的癌细胞
7. Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the Uterine Cervix [O] . Natalia Smaglyukova, Elise Thoresen Sletten, Anne Ørbo, 2020

机译：关于核孕酮受体（NPR），膜孕酮受体（MPR）和孕酮受体膜组分（PGRMC）的数据来自人子宫子宫子宫内膜组织和子宫子宫颈的癌细胞
8. Human Erythrocyte Membrane Uptake of Progesterone and Chemical Alterations [R] . DeVenuto, F., Ligon, D. F., Friedrichsen, D. H., 1969

机译：人红细胞膜摄取黄体酮和化学改变

Progesterone diffusion through snake skin as a human model membrane

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