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首页> 外文期刊>International journal of design engineering >Development of a nanoparticle microfluidic colour device for point-of-care diagnostics
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Development of a nanoparticle microfluidic colour device for point-of-care diagnostics

机译：用于即时诊断的纳米微流控彩色设备的开发

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Through a novel immunoassay nanoparticles (NPs) are captured via immune-reactive proteins and positioned as a sub-monolayer just a few nanometres above a light reflective surface. Here the particles and the mirror form a nanometric interference system with a tuneable colour throughout the full spectrum of light. This concept, which was inspired by nature ('wings of a butterfly'), creates an intensive colour clearly visible to the eye. By adaptation of this technique point-of-care (POC) tests become more sensitive, specific and time efficient. The novel format employs a combination of microfluidics and 'resonance-enhanced absorption' (REA) of gold and palladium nanoparticles quantifying interleukin-6 as an important parameter of acute sepsis. The colour intensity of the rapid test is boosted by using a subsequent silver enhancement. This performed in situ in just two to three minutes and a sensitivity of < 500 pg/ml was obtained.
机译：通过一种新型的免疫测定，纳米颗粒（NPs）通过免疫反应蛋白被捕获，并被定位为亚单层，位于光反射表面上方几纳米处。在这里，粒子和反射镜形成一个纳米干涉系统，在整个光谱范围内具有可调整的颜色。这个概念受到自然界（“蝴蝶的翅膀”）的启发，创造了一种清晰可见的强烈色彩。通过采用这种技术，即时医疗（POC）测试变得更加灵敏，专一且省时。这种新型形式结合了微流控技术和金和钯纳米粒子的“共振增强吸收”（REA），将白介素-6定量为急性败血症的重要参数。快速测试的颜色强度通过使用后续的银增强来增强。仅在两到三分钟内就可以进行原位检测，灵敏度<500 pg / ml。

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