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首页> 外文期刊>International Journal of Heat and Fluid Flow >Rheological and dynamical characterization of blood analogue flows in a slit
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Rheological and dynamical characterization of blood analogue flows in a slit

机译：狭缝中血液类似物流的流变和动力学表征

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Thrombus formation and haemolysis are blood destructive phenomena depending on the flow hydrodynamics, particularly the shear stresses. This work addresses this issue by characterizing experimentally (using the micro-PIV technique) and numerically (using CFD) steady-state Newtonian (water and water/glycerine solutions) fluid flows and non-Newtonian (water/glycerine/xanthan) blood analogue flows, in a slit with a height of 1.3 mm and a width of 30 mm. The results obtained may provide useful information in the design of extracorporeal devices manipulating blood for diagnosis and therapeutics. Results from CFD showed that the Herschel-Bulkley viscosity model yields velocity predictions in excellent agreement with the experimental data obtained with the micro-PIV. Viscosity measurements evidenced that the water/glycerine (35% w/w)/xanthan (0.02% w/w) solution mimics well the blood global viscosity, exhibiting velocity profile shapes in fully developed flows flattened at the centre, typical of shear-thinning fluids. The maximum shear stresses obtained experimentally (1.39-3.11 Pa) for the blood analogue flows at the studied rates (6.7-25.3 L/h) evidence that haemolysis is unlikely to occur since lysis threshold values are 150 Pa for erythrocytes, 10 Pa for leucocytes and 7.5 Pa for platelets. However, the smallest flow rate cases may be of concern in blood circulation by yielding clot formation near the walls since the shear stresses there are bellow the thrombus/coagulation threshold (1.0-1.8 Pa).
机译：血栓形成和溶血是血液的破坏现象，这取决于流动的流体动力学，尤其是剪切应力。这项工作通过实验表征（使用微型PIV技术）和数值表征（使用CFD）稳态牛顿（水和水/甘油溶液）流体流和非牛顿（水/甘油/黄原胶）血液类似物流来解决此问题。 ，其高度为1.3毫米，宽度为30毫米。获得的结果可为设计用于诊断和治疗的血液的体外装置的设计提供有用的信息。 CFD的结果表明，Herschel-Bulkley粘度模型产生的速度预测与使用微型PIV获得的实验数据非常吻合。粘度测量结果表明，水/甘油（35％w / w）/黄原胶（0.02％w / w）溶液很好地模拟了血液的整体粘度，在完全展平的中心流中表现出速度剖面形状，这是典型的剪切稀化液体。以研究速率（6.7-25.3 L / h）实验获得的血样流的最大剪切应力（1.39-3.11 Pa）表明溶血不太可能发生，因为红细胞的裂解阈值为150 Pa，白细胞的裂解阈值为10 Pa血小板为7.5 Pa。但是，由于在血流/凝结阈值（1.0-1.8 Pa）以下，剪应力在壁附近产生凝块，因此在血液循环中可能需要考虑最小流速情况。

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