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首页> 外文期刊>International Journal of Heat and Mass Transfer >Two-phase flow and heat transfer in a self-developed MRI compatible LN_2 cryoprobe and its experimental evaluation
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Two-phase flow and heat transfer in a self-developed MRI compatible LN_2 cryoprobe and its experimental evaluation

机译：自行开发的MRI兼容LN_2低温探头的两相流动和传热及其实验评价

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摘要

Cryosurgery is a new alternative surgical treatment compared with other traditional methods. However, it is hampered to standard cancer treatment due to some limitations. One is difficult to accurately monitor the extent of frozen tissue of internal organs during treatment. Another is insufficient freezing effect in the edge of the frozen region which leads to recurrence and metastasis of tumors. The approach of magnetic resonance imaging (MRI) is used to overcome such type of drawbacks during cryosurgery. The reason is that MRI could be explored to guide the puncture process and also monitor the developed frozen region throughout the cryoablation. Also, the iceball monitoring approaches could help to reduce the cell death of non-cancerous tissues. However, none of the studies enunciated the MRI compatible liquid nitrogen (LN2) cryoprobe based cryosurgery system to demonstrate the thermal evaluation during the treatment of carcinoma tissue. In this study, we established the MRI compatible LN2 cryoprobe based cryosurgery system to accurately destroying cancerous tissue while minimizing the destruction of healthy tissue. An unsteady two-phase flow and coupled heat transfer model was used to analyze the dynamics of the temperature fields developing in biological tissue during cryosurgery. The 3.0-T MRI system was applied to monitor the iceball propagation and detect the artifacts caused by the cryoprobe in cryosurgery. In vitro experiment was performed in porcine liver and further used in MRI approach. The results revealed that the ice ball diameter was approximately 4 cm determined by MRI approach after 500 s freezing both in phantom and porcine liver cases. Cell killing experiment with 0.1% (w/v) Fe3O4 nanoparticles was also conducted to overcome the edge effect and enlarge the effective killing region of entire iceball, found that there was no additional damage to the surrounding unfrozen tissue. All these methodologies show that the developed cryoprobe could be a potential to be adopted in MRI guided cryosurgeries that could be precisely watched the frozen propagation inside the diseased tissue. These findings may further promote the cryosurgery to be a more effective thermal treatment. (C) 2019 Elsevier Ltd. All rights reserved.
机译：与其他传统方法相比，冷冻外科是一种新的替代手术治疗。然而，由于某些限制，它妨碍了标准的癌症治疗。一种在治疗期间难以准确地监测内部器官的冷冻组织的程度。另一个是在冷冻区域边缘的冷冻效果不足，这导致肿瘤的复发和转移。磁共振成像（MRI）的方法用于克服冷冻手术期间的此类缺陷。原因是可以探索MRI来指导穿刺过程，并在整个冷冻消融过程中监测显影的冷冻区域。而且，冰球监测方法可以帮助减少非癌性组织的细胞死亡。但是，没有一项研究阐明基于MRI兼容液氮（LN2）的冷冻探头冷冻系统，以证明在治疗癌组织期间的热评估。在这项研究中，我们建立了基于MRI兼容LN2冷冻探头的冷冻手术系统，可以精确地破坏癌组织，同时最大程度地减少对健康组织的破坏。非稳态两相流动和耦合传热模型用于分析冷冻手术过程中生物组织中温度场的动态变化。 3.0-T MRI系统用于监测冰球的传播并检测冷冻手术中由冷冻探针引起的伪影。在猪肝中进行了体外实验，并进一步用于MRI方法。结果表明，在幻影和猪肝病例中，冷冻500 s后，通过MRI方法测定的冰球直径约为4 cm。还进行了使用0.1％（w / v）Fe3O4纳米粒子的细胞杀灭实验，以克服边缘效应并扩大整个冰球的有效杀伤区域，发现对周围未冷冻的组织没有其他损害。所有这些方法论都表明，开发的冷冻探针有可能在MRI引导的冷冻手术中被采用，可以精确地观察到冷冻在患病组织内部的传播。这些发现可能进一步促进冷冻手术成为更有效的热处理。 （C）2019 Elsevier Ltd.保留所有权利。

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  • 来源
  • 作者

    Zhang Xin; Hossain S. M. Chapal; Wang Qiang; Qiu Bensheng; Zhao Gang;

  • 作者单位

    Univ Sci & Technol China, Dept Elect Sci & Technol, Hefei 230027, Anhui, Peoples R China;

    Univ Sci & Technol China, Dept Elect Sci & Technol, Hefei 230027, Anhui, Peoples R China|Jagannath Univ, Dept Math, Dhaka 1100, Bangladesh;

    Xuzhou Canc Hosp, Dept Radiat Oncol, Xuzhou 221005, Jiangsu, Peoples R China;

    Univ Sci & Technol China, Dept Elect Sci & Technol, Hefei 230027, Anhui, Peoples R China;

    Univ Sci & Technol China, Dept Elect Sci & Technol, Hefei 230027, Anhui, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Magnetic resonance imaging; LN2 cryoprobe; Fe3O4 nanoparticles; Two-phase flow;

    机译：磁共振成像;LN2低温探针;Fe3O4纳米颗粒;两相流;

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