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首页> 外文期刊>International Journal of Heat and Mass Transfer >Computational evaluation of malignant tissue apoptosis in magnetic hyperthermia considering intratumoral injection strategy
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Computational evaluation of malignant tissue apoptosis in magnetic hyperthermia considering intratumoral injection strategy

机译：考虑肿瘤内注射策略磁体热疗恶性组织凋亡的计算评价

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摘要

Magnetic hyperthermia can result in the apoptosis of malignant cells and the safety of normal cells when bio-tissue contained magnetic nanoparticles (MNPs) is exposed to a specific range of treatment temperature due to an applied magnetic field. Magnetic hyperthermia covers lots of different aspects while earlier studies focused primarily on one of them and less on their correlations. This paper develops a set of theoretical and mathematical model to evaluate the apoptosis behavior for a proposed geometric model, in which intratumoral injection of nanofluid is considered for therapy. This framework mainly integrates the applied magnetic field due to a proposed solenoid coil, the nanofluid concentration field after the intratumoral injection, and the treatment temperature field due to the power dissipation of MNPs. The magnetic and concentration fields can determine the heat production of MNPs, which is significantly relevant to the apoptosis situation due to the treatment temperature distribution inside tumor region during therapy. These three physical fields can be predicted by solving their individual partial differential equations using finite element method after considering their initial and boundary conditions. Simulation results demonstrate that the proposed approach can be used to model the entire process of magnetic hyperthermia and the apoptosis situation of malignant cells can be predicted by the coupling manner for three different fields during therapy. In addition, the apoptosis situation can be effectively improved when a specific critical power dissipation of MNPs is designed for different nanofluid concentration distribution with different diffusion duration. With further developments, this proposed model may be used for the planning of nanofluid hyperthermia.
机译：磁体热热可导致恶性细胞的凋亡和正常细胞的安全性，当生物组织含有的磁性纳米颗粒（MNP）暴露于由于施加的磁场引起的特定处理温度。磁体热疗涵盖了许多不同的方面，而早期的研究主要集中在其中一个，并少于它们的相关性。本文开发了一系列理论和数学模型，以评估所提出的几何模型的凋亡行为，其中考虑了纳米流体的肿瘤内注射治疗。该框架主要集成了所施加的磁场，由于所提出的螺线管线圈，纳米流体注射后的纳米流体浓度场，以及由于MNP的功率耗散而导致的处理温度场。磁性和浓度场可以确定MNP的热量产生，这与治疗期间肿瘤区域内的治疗温度分布引起的凋亡情况显着相关。通过在考虑其初始和边界条件之后，可以通过使用有限元方法解决各个部分微分方程来预测这三个物理场。仿真结果表明，所提出的方法可用于模拟磁热疗的整个过程，并且可以通过治疗期间三种不同场的耦合方式预测恶性细胞的细胞凋亡情况。此外，当MnP的特定临界功率耗散设计用于不同扩散持续时间的不同纳米流体浓度分布时，可以有效地改善细胞凋亡情况。通过进一步的发展，该拟议的模型可用于纳米流体热疗的规划。

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