Studying of the thermal performance of a hybrid cryo-RFA treatment of a solid tumor

Y.L. Shao; H.L. Leo; K.J. Chua

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Studying of the thermal performance of a hybrid cryo-RFA treatment of a solid tumor

机译：混合冷冻-RFA治疗实体瘤的热性能研究

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Both cryosurgery and radiofrequency ablation (RFA) for solid liver tumor treatment are available as minimally invasive procedures that induce changes to the tumor’s thermal environment in order to destroy cancer cells. However, one of the critical factors that impedes cryosurgery and RFA’s successful outcomes is the relatively high recurrence rate caused by the inability to ablate a large damaged tissue zone that envelopes targeted tumors, resulting in therapy failure. To overcome these challenges, a hybrid cryo-RFA system under thermal stress control is proposed in this study. A three-dimensional finite difference analysis is employed to simulate the combined cryosurgery and RF heating protocol. Based on the data acquired from measured experiments, the simulated results derived have demonstrated close agreement with experimental data, with a maximum deviation of 4.8%. We investigated the impacts of varying cryoprobe’s holding temperature and cooling rates on tissue damage. Results have revealed that the tissue damage region is enhanced by properly increasing the cryoprobe’s cooling rate, but the increase of cryoprobe’s cooling rate cannot enlarges the tissue damage area without limit in the freezing process. In addition, the employment of a hybrid cryo-RFA system markedly promotes the destruction of cancer tissue in contrast to conventional stand-alone RF heating or cryosurgery.

机译：用于实体肝肿瘤治疗的冷冻外科手术和射频消融（RFA）均可作为微创手术来使用，这些手术可引起肿瘤热环境的改变，从而破坏癌细胞。但是，阻碍冷冻手术和RFA成功结果的关键因素之一是由于无法消融覆盖目标肿瘤的大面积受损组织区域而导致的相对较高的复发率，从而导致治疗失败。为了克服这些挑战，本研究提出了一种在热应力控制下的混合低温RFA系统。使用三维有限差分分析来模拟冷冻手术和射频加热方案的组合。根据从实测实验获得的数据，得出的模拟结果与实验数据非常吻合，最大偏差为4.8％。我们研究了不同的冷冻探针保持温度和冷却速率对组织损伤的影响。结果表明，适当增加冷冻探针的冷却速率可以增强组织损伤区域，但是增加冷冻探针的冷却速率并不能扩大组织损伤区域，而不会限制冷冻过程。另外，与常规的独立RF加热或冷冻手术相比，使用混合冷冻RFA系统显着促进了癌组织的破坏。

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来源
《International Journal of Heat and Mass Transfer》 |2018年第7期|410-420|共11页
作者
Y.L. Shao; H.L. Leo; K.J. Chua;
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作者单位

Department of Mechanical Engineering, National University of Singapore;

Department of Biomedical Engineering, National University of Singapore;

Department of Mechanical Engineering, National University of Singapore;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
Thermal stress; Cell injury; Thermal model; Cryosurgery; RFA matrix system;

机译：热应力细胞损伤热模型冷冻外科RFA矩阵系统;

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Studying of the thermal performance of a hybrid cryo-RFA treatment of a solid tumor

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