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Critical time scales for morphogen gradient formation: Concentration or gradient criteria?

机译:形态发生子梯度形成的关键时间尺度:浓度或梯度标准?

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摘要

We extend some recent analysis regarding an approximation of the time scale required for a transient morphogen concentration profile to approach steady state. Motivated by experimental observations, we consider the time scale required for the spatial gradient of morphogen concentration to approach steady state. The analysis shows that the spatial gradient approaches steady state faster than the associated concentration profile approaches steady state. For typical parameter values, this difference in time scales appears to be significant because it is comparable to the time scale of a typical experiment.
机译:我们扩展了一些有关瞬时形态发生子浓度曲线接近稳态所需的时间尺度的近似分析。受实验观察的启发,我们考虑了形态发生子浓度的空间梯度趋于稳态所需的时间尺度。分析表明,空间梯度接近稳态要快于相关的浓度分布接近稳态。对于典型的参数值,时标上的这种差异似乎很明显,因为它可以与典型实验的时标相比。

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