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首页> 外文期刊>International Journal of Heat and Mass Transfer >Estimation of the porosity of a chitosan-carbon nanoparticle membrane fabricated on a chip: A solute transport-based study
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Estimation of the porosity of a chitosan-carbon nanoparticle membrane fabricated on a chip: A solute transport-based study

机译：估计芯片上制备的壳聚糖-碳纳米颗粒膜的孔隙率：基于溶质迁移的研究

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摘要

Porosity is an important parameter by which to evaluate membrane performance. In recent years, membranes formed in microfiuidic chips using laminar flow-based interfacial reaction technology have gained extensive attention due to their potential in micro-separation applications; however, so far, there has not been a feasible method to determine the porosity because of the very tiny size of this type of membrane. Here, we proposed a solute transport-based method to estimate the porosity of a chitosan-carbon nanoparticle membrane fabricated in a microdevice. In this method, a counter-current microdialysis mode was designed to experimentally study urea transport across the membrane, and a fluorescein was added to the urea solution to facilitate the observation of the urea concentration profile. Then, a porosity-related mass transfer model was developed to theoretically simulate the urea transport. The membrane porosity was obtained by iterating the porosity distribution to minimize the difference between the theoretical and experimental results. Finally, the membrane porosity was experimentally validated through a creatinine clearance study. The averaged porosities of the on-chip chitosan-carbon nanoparticle membrane formed in 15, 20, and 25min were 0.356 ±0.050, 0.242 ±0.018 and 0.235 ± 0.009, respectively. The method proposed here is of significance for characterizing the performance of on-chip fabricated membranes.
机译：孔隙率是评估膜性能的重要参数。近年来，由于其在微分离应用中的潜力，使用基于层流的界面反应技术在微流体芯片中形成的膜受到了广泛关注。然而，由于这种类型的膜的尺寸非常小，因此到目前为止，尚无可行的方法来确定孔隙率。在这里，我们提出了一种基于溶质输运的方法来估算微器件中制备的壳聚糖-碳纳米颗粒膜的孔隙率。在这种方法中，设计了逆流微透析模式，以实验研究尿素在膜上的传输，并向尿素溶液中添加了荧光素，以方便观察尿素浓度曲线。然后，开发了孔隙率相关的传质模型，以理论上模拟尿素的传输。通过迭代孔隙率分布以最小化理论结果与实验结果之间的差异来获得膜孔隙率。最后，通过肌酐清除率研究对膜的孔隙率进行了实验验证。在15、20和25分钟内形成的芯片上壳聚糖-碳纳米颗粒膜的平均孔隙率分别为0.356±0.050、0.242±0.018和0.235±0.009。这里提出的方法对于表征芯片上制造的膜的性能具有重要意义。

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  • 作者

    Weiping Ding; Xingxia Zhu; Lili Zou; Jing Liu; Dongmin Wang; Cheng Liang; Chengpan Li; Liqun He;

  • 作者单位

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China,Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China;

    Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Porosity; Solute transport; Membrane; Microfluidics; Microdialysis;

    机译：孔隙率溶质运输;膜;微流体;微透析;

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