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首页> 外文期刊>International Journal of Heat and Mass Transfer >A mass transfer model of temporal drug deposition in artery walls
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A mass transfer model of temporal drug deposition in artery walls

机译：药物在动脉壁中沉积的传质模型

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摘要

A new mass transfer model has been formulated and implemented for predicting the penetration of liquid medication into an arterial wall. The model takes separate account of the transport of medication in the tissue and in the liquid stream. The transport equations take into consideration both diffusion and advection. An original lateral transport mechanism relating the drug concentrations in the tissue and in the advecting liquid stream is postulated and calibrated with experimental data from the literature. The special features of the mechanism are its non-Fickian nature and the accounting of the affinity (binding) of the drug to the tissue. Once established, the model was applied by means of numerical simulation to the in-artery distribution of Paditaxel, a drug whose function is to minimize restenosis of the artery wall. The application encompassed parametric values of the duration of the drug therapy, the viscosity of the advecting fluid, and the pressure used to drive the drug into the tissue. It was found that the drug concentration at a clinically relevant depth in the artery wall varied linearly with the duration of the therapy, increased with increasing values of the driving pressure, and decreased for higher viscosities of the advecting fluid. In addition to its capabilities for predicting drug concentrations during the therapy duration period, the simulations also were able to follow the temporal variations of the drug distribution after the cessation of the therapy.
机译：已经制定并实施了一种新的传质模型，用于预测液体药物向动脉壁的渗透。该模型单独考虑了药物在组织和液流中的传输。输运方程式同时考虑了扩散和对流。提出了与组织和平流液流中的药物浓度相关的原始横向运输机制，并用文献中的实验数据进行了校准。该机制的特殊特征是其非费克式性质以及药物与组织的亲和力（结合力）。一旦建立，该模型将通过数值模拟的方法应用于Paditaxel的动脉内分布，该药物的功能是最大程度地减少动脉壁的再狭窄。该应用包括药物治疗的持续时间，平流液的粘度以及用于将药物驱动到组织中的压力的​​参数值。已经发现，在动脉壁的临床相关深度处的药物浓度随治疗持续时间线性地变化，随驱动压力值的增加而增加，而对于较高粘度的吸收流体则降低。除了可以预测治疗持续时间期间的药物浓度外，模拟还能够跟踪停止治疗后药物分布的时间变化。

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  • 作者

    J.P. Abraham; J.M. Gorman; E.M. Sparrow; J.R. Stark; R.E. Kohler;

  • 作者单位

    School of Engineering, University of St. Thomas, St. Paul, MN 55105, USA;

    Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA;

    Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA;

    School of Engineering, University of St. Thomas, St. Paul, MN 55105, USA Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA;

    Cardiovascular Systems, Inc., St. Paul, MN 55! 12, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Paditaxel; Drug diffusion; Cardiovascular disease; Mass transfer; Artery wall;

    机译：Paditaxel;药物扩散;心血管疾病;传质;动脉壁;

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