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首页> 外文期刊>International Journal of Heat and Mass Transfer >Heat transfer analysis for the design and application of the passive cooling rate controlled device-Box-in-box
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Heat transfer analysis for the design and application of the passive cooling rate controlled device-Box-in-box

机译：传热分析在被动冷却速率控制装置的设计和应用中的应用

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摘要

Background: In cryopreservation, cooling rate is a dominant factor that influences the survival of cells. Box-in-box (BIB) was recently developed as a reliable, cooling rate controlled and cost-effective cooling device. However, the intrinsic heat transfer characteristic still needs to be further specified for the best of design and application of the device. Method: The freezing process of samples inside BIB is simulated by developing a one dimensional heat transfer model in which fixed-grid technique is used to solve the solidification problem of the ternary cryopreservation media (water, NaCl and cryoprotectant). Based on the model, several critical factors, including supercooling temperature, structural parameters and application conditions, are evaluated respectively. Several cell free experiments were also conducted to validate the model. Results: It was demonstrated that BIB method can achieve uniform and consistent cooling of samples, and the theoretical and experimental results fit quite well. Further analysis reveals that several structural parameters (such as the dimension of insulation layer) and application conditions (such as the cryoprotectant concentration and the sample volume) have significant effect on the freezing process of sample. Thus the design and application of BIB should be carefully conducted to achieve the desired cooling rate. Conclusion: The theoretical model is reasonable for the BIB system. It provides an effective tool to determine the detailed structural parameters when designing BIBs, and it can also be used as a good support for the application of BIB systems.
机译：背景：在冷冻保存中，冷却速率是影响细胞存活的主要因素。箱中盒（BIB）最近被开发为一种可靠的，受冷却速率控制且具有成本效益的冷却设备。然而，为了使装置的设计和应用达到最佳，仍需要进一步规定固有的传热特性。方法：通过建立一维传热模型来模拟BIB内部样品的冷冻过程，该模型使用固定网格技术解决三元冷冻保存介质（水，NaCl和冷冻保护剂）的固化问题。基于该模型，分别评估了多个关键因素，包括过冷温度，结构参数和应用条件。还进行了几次无细胞实验以验证模型。结果：证明了BIB方法可以实现样品的均匀一致冷却，理论和实验结果吻合得很好。进一步的分析表明，几个结构参数（例如隔热层的尺寸）和使用条件（例如防冻剂浓度和样品量）对样品的冷冻过程具有重要影响。因此，应仔细进行BIB的设计和应用，以达到所需的冷却速度。结论：该理论模型对于BIB系统是合理的。它是设计BIB时确定详细结构参数的有效工具，也可以为BIB系统的应用提供良好的支持。

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  • 来源
    《International Journal of Heat and Mass Transfer》 |2011年第10期|p.2136-2143|共8页
  • 作者

    Xiaoming Zhou; Zhiaquan Shu; Weiping Ding; Shelly Heimfeld; JaeHyun Chung; Pingan Du; Carolyn Liu; Dayong Gao;

  • 作者单位

    School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China,Department of Mechanical Engineering. University of Washington, Seattle, WA 98195. USA;

    Department of Mechanical Engineering. University of Washington, Seattle, WA 98195. USA;

    Department of Mechanical Engineering. University of Washington, Seattle, WA 98195. USA;

    Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109,USA;

    Department of Mechanical Engineering. University of Washington, Seattle, WA 98195. USA;

    School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China;

    Swedish Physicians Pine Lake Clinic, Sammamish, WA 98075, USA;

    Department of Mechanical Engineering. University of Washington, Seattle, WA 98195. USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    heat transfer model; cooling rate; box-in-box; cryopreservation;

    机译：传热模型冷却速率箱中盒低温保存;

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