A multi-layer porous wall model for coronary drug-eluting stents

Giuseppe Pontrelli; Filippo de Monte

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A multi-layer porous wall model for coronary drug-eluting stents

机译：冠状动脉药物洗脱支架的多层多孔壁模型

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An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial differential equations. The classical separation of variables method for a multi-layer configuration is used. The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass pro-flies in each layer at various times are given and discussed.

机译：提出了一种解决瞬态药物在面对药物洗脱支架的多孔壁层中扩散的解析解决方案。内皮，内膜，内部弹性层和介质均被视为均质的多孔介质，并且通过它们的药物传递通过一组耦合的偏微分方程建模。使用多层配置的经典变量分离方法。该模型解决了多层固体穿透深度的概念，该概念可通过估计质量扩散的物理边界来处理壁厚。给出并讨论了各层在不同时间的药物浓度水平和质量分布。

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来源
《International Journal of Heat and Mass Transfer》 |2010年第20期|P.3629-3637|共9页
作者
Giuseppe Pontrelli; Filippo de Monte;
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作者单位

Istituto per le Applicazioni del Calcolo - CNR, Via dei Taurini 19, 00185 Roma, Italy;

rnDipartimento di Ingegneria Meccanica, Energetica e Gestionale University of L'Aquila, Localita Monteluco, 67040 Roio Poggio (AQ), Italy;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
mass transfer; multi-layered porous media; advection-diffusion equation; multi-layer penetration depth; drug delivery; pharmacokinetics;

机译：传质多层多孔介质对流扩散方程;多层穿透深度药物输送;药代动力学;

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1. LINEAR AND QUADRATIC IMMERSED FINITE ELEMENT METHODS FOR THE MULTI-LAYER POROUS WALL MODEL FOR CORONARY DRUG-ELUTING STENTS [J] . Zhang Huili, Lin Tao, Lin Yanping International journal of numerical analysis and modeling . 2018,第1a2期

机译：用于冠状动脉洗脱支架多层多孔壁模型的线性和二次浸没有限元方法
2. An advection-diffusion multi-layer porous model for stent drug delivery in coronary arteries [J] . De Monte Filippo, Valipour Mohammad Sadegh, Vahedi Seyed Masoud Journal of Computational and Applied Research in Mechanical Engineering (JCARME) . 2019,第1期

机译：冠状动脉支架药物递送的平流扩散多层多孔模型
3. Coronary arterial remodeling and out-stent plaque change after drug-eluting stent implantation - Comparison between zotarolimus-eluting stents and paclitaxel-eluting stents [J] . MuraokaY., SonodaS., KashiyamaK., Circulation journal . 2013,第2期

机译：药物洗脱支架植入后的冠状动脉重塑和支架外斑块变化-佐他莫司洗脱支架与紫杉醇洗脱支架的比较
4. Mathematical Modeling for the Design of Porous Coronary Stents: Nano- and Microporous Stents v. Macroporous Stents [C] . Anwer K Habib, Aloke V Finn Conference on nanosensors, biosensors, and info-tech sensors and systems . 2010

机译：多孔冠状动脉支架设计的数学模型：纳米多孔支架与大孔支架
5. Continuum deformation model for drug-eluting stent (DES) medical devices using finite element analysis (FEA) [D] . Lee, Solki 2013

机译：使用有限元分析（FEA）的药物洗脱支架（DES）医疗设备的连续体变形模型
6. Comparison between the Outcomes of Using Biodegradable-Polymer Drug-Eluting Stents and Those of Using Durable-Polymer Drug-Eluting Stents in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention [O] . Abd-Allah Y. Fawzy, Mahmoud M. Kenawi, Ahmed Abd El Aziz, 2019

机译：经皮冠状动脉介入治疗的急性冠脉综合征患者使用生物可降解药物洗脱支架与使用耐用聚合物药物洗脱支架的结果比较
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A multi-layer porous wall model for coronary drug-eluting stents

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