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首页> 外文期刊>International Journal of Hygiene and Environmental Health >The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals
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The European human biomonitoring platform - Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals

机译：欧洲人类生物监测平台 - 设计和实施实验室质量保证/质量控制（QA / QC）计划，用于选定的优先化学品

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摘要

A fundamental objective of the human biomonitoring for Europe initiative (HBM4EU) is to progress toward comparable and robust exposure data for a wide variety of prioritized chemicals in human samples. A programme for Quality Assurance/Quality Control (QA/QC) was designed in HBM4EU with the purpose of creating a network of European laboratories providing comparable analytical data of high quality. Two approaches were chosen for two sets of prioritized chemicals with different timelines: (i) Scheme 1, where interested candidate laboratories participated in multiple rounds of proficiency tests (ii) Scheme 2, where selected expert laboratories participated in three rounds of interlaboratory comparison investigations. In both cases, the results were used to identify laboratories capable of generating consistent and comparable results for sample analysis in the frame of HBM4EU. In total, 84 laboratories from 26 countries were invited to participate in Scheme 1 that covered up to 73 biomarkers from Hexamoll® DINCH, phthalates, bisphenols, per- and polyfluoroalkyl substances, halogenated flame retardants (HFRs), organophosporous flame retardants (OPFRs), polycyclic aromatic hydrocarbons (PAH), cadmium, chromium and aromatic amines. 74 of the participants were successful for at least one biomarker in Scheme 1. Scheme 2 involved 22 biomarkers and successful results were obtained by 2 expert laboratories for arsenic, 5 for acrylamide, 4 for mycotoxins, 2 for pesticides and 2 for UV-filters in skin care products. The QA/QC programme allowed the identification of major difficulties and needs in HBM analysis as well of gaining insight in the analytical capacities of European laboratories. Furthermore, it is the first step towards the establishment of a sustainable European network of HBM laboratories.
机译：对欧洲倡议（HBM4EU）的人类生物监动的基本目标是对人类样品中各种优先化化学品进行可比和强大的曝光数据。质量保证/质量控制（QA / QC）计划于HBM4EU设计，目的是创建欧洲实验室网络，提供高质量的可比分析数据。选择两种方法，采用不同的时间表：（i）计划1，有兴趣的候选实验室参加了多轮熟练试验（II）计划2，选定的专家实验室参加了三轮的间接比较调查。在这两种情况下，结果用于鉴定能够在HBM4EU框架中产生一致和可比结果的实验​​室。总共有84个国家的实验室被邀请参加计划1，从六莫尔博希，邻苯二甲酸酯，双酚，每氟氟烷基，卤化阻燃剂（HFRS），有机孢子阻燃剂（OPFR），多环芳烃（PAH），镉，铬和芳族胺。参与者的74人在方案中的至少一种生物标志物中成功。方案2涉及22个生物标志物和成功的结果是通过2个专家实验室为砷，5用于丙烯酰胺，4用于霉菌毒素，2用于杀虫剂，2用于杀虫剂，2用于紫外线过滤器护肤品。 QA / QC计划允许识别HBM分析中的主要困难和需求以及在欧洲实验室分析能力的洞察中获得洞察力。此外，它是建立一个可持续欧洲HBM实验室网络的第一步。

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  • 来源
    《International Journal of Hygiene and Environmental Health》 |2021年第5期|113740.1-113740.9|共9页
  • 作者

    Esteban Lopez M.; Pedraza - Diaz S.; Castano A.; Goen T.; Nubler S.; Haji-Abbas-Zarrabi K.; Mol H.; Elbers I.; Koch H.M.; Kasper-Sonnenberg M.; Dvorakova D.; Hajslova J.; Antignac J.-P.; Vaccher V.; Thomsen C.; Vorkamp K.; Kolossa-Gehring M.;

  • 作者单位

    National Centre for Environmental Health Instituto de Salud Carlos III (ISCIII) Majadahonda Spain;

    Institute and Outpatient Clinic of Occupational Social and Environmental Medicine Friedrich-Alexander Universität Erlangen-Nürnberg (IPASUM) Erlangen Germany;

    Wageningen Food Safety Research Part of Wageningen University & Research Wageningen Netherlands;

    Institute and Outpatient Clinic of Occupational Social and Environmental Medicine Friedrich-Alexander Universität Erlangen-Nürnberg (IPASUM) Erlangen Germany;

    Institute and Outpatient Clinic of Occupational Social and Environmental Medicine Friedrich-Alexander Universität Erlangen-Nürnberg (IPASUM) Erlangen Germany;

    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of the Ruhr-University-Bochum (IPA) Bochum Germany;

    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of the Ruhr-University-Bochum (IPA) Bochum Germany;

    Department of Food Analysis and Nutrition Faculty of Food and Biochemical Technology University of Chemistry and Technology (UCT) Prague Czech Republic;

    Department of Food Analysis and Nutrition Faculty of Food and Biochemical Technology University of Chemistry and Technology (UCT) Prague Czech Republic;

    Oniris INRAE LABERCA Nantes France;

    Oniris INRAE LABERCA Nantes France;

    Wageningen Food Safety Research Part of Wageningen University & Research Wageningen Netherlands;

    Department of Environmental Health Norwegian Institute of Public Health (NIPH) Oslo Norway;

    Department of Environmental Science Aarhus University (AU) Roskilde Denmark;

    German Environment Agency (UBA) Berlin Germany;

    National Centre for Environmental Health Instituto de Salud Carlos III (ISCIII) Majadahonda Spain;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    External; HBM4EU; Human biomonitoring (HBM); Interlaboratory comparison investigation (ICI); Quality assurance scheme (EQUAS);

    机译：外部;HBM4EU;人类生物监测（HBM）;互制态比较调查（ICI）;质量保证计划（方程）;

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