Multiphysics and Multiscale Simulation: Application to a Coupled Model of the Left Ventricle and a Mechanical Heart Valve

V. Diaz-Zuccarini; D. R. Hose; P. V. Lawford; A. J. Narracott; D. Rafiroiu

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Multiphysics and Multiscale Simulation: Application to a Coupled Model of the Left Ventricle and a Mechanical Heart Valve

机译：多物理场和多尺度模拟：在左心室和机械心脏瓣膜耦合模型中的应用

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摘要

This work combines a number of diverse disciplines (physiology, biomechanics, fluid mechanics, and simulation) in order to develop a predictive model of the behavior of a prosthetic heart valve in vivo. The application of simulation to the study of other cardiovascular problems, such as blood clotting, is also discussed. A commercial, finite volume, computational fluid dynamics (CFD) code (ANSYS/CFX) is used for the three-dimensional (3D) component of the model. A multiscale approach is taken to produce a model of left ventricular function, from the level of the contractile proteins to the resulting ventricular pressure, to provide detailed boundary conditions for the 3D CFD model. We present results from the 3D model and discuss their implications in the context of the cavitation potential of the valve. The results suggest that the use of this approach allows us to address complex cardiovascular problems in greater detail and in a more physiologically orientated manner.

机译：这项工作结合了许多不同的学科（生理学，生物力学，流体力学和模拟），以便开发出人工心脏瓣膜在体内行为的预测模型。还讨论了模拟在研究其他心血管问题（例如凝血）中的应用。商业的有限体积计算流体动力学（CFD）代码（ANSYS / CFX）用于模型的三维（3D）组件。从收缩蛋白的水平到产生的心室压力，采用多尺度方法来产生左心室功能模型，从而为3D CFD模型提供详细的边界条件。我们介绍了3D模型的结果，并讨论了在阀门气蚀潜力的背景下它们的含义。结果表明，这种方法的使用使我们能够更详细，更符合生理学的方式解决复杂的心血管问题。

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《International Journal for Multiscale Computational Engineering》 |2008年第1期|p.65-76|共12页
作者
V. Diaz-Zuccarini; D. R. Hose; P. V. Lawford; A. J. Narracott; D. Rafiroiu;
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作者单位

University of Sheffield, Academic Unit of Medical Physics, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK;

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原文格式 PDF
正文语种 eng
中图分类建筑科学;
关键词
cardiovascular modelling and simulation; multiscale modelling; left ventricle; cardiac valves; 3D modelling; lumped parameter modelling; boundary conditions; cavitation; blood clotting;

机译：心血管建模与仿真;多尺度建模;左心室;心脏瓣膜;3D建模;集总参数建模;边界条件;空化;血液凝结;

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Multiphysics and Multiscale Simulation: Application to a Coupled Model of the Left Ventricle and a Mechanical Heart Valve

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