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首页> 外文期刊>International journal of non-linear mechanics >DNA stretching modeled at the base pair level: Overtwisting and shear instability in elastic linkages
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DNA stretching modeled at the base pair level: Overtwisting and shear instability in elastic linkages

机译：在碱基对水平上建模的DNA拉伸：弹性连接中的过度扭曲和剪切不稳定性

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Stretching experiments on single DNA molecules indicate that, counterintuitive to expectations, DNA overwinds when stretched and, at large forces, undergoes a transition into an overstretched form indicated by a plateau on the force-displacement diagrams. It is believed that these effects are the result of non-linearities in the elastic response of DNA. We use a discrete, base pair level model to simulate the behavior of short DNA molecules, taking into account the sequence dependent physical properties of DNA alongside with the coupling between the kinematical step parameters, yet retaining the quadratic form of local elastic energy function. By constructing bifurcation diagrams of equilibrium configurations and studying the dependence on base pair combinations we show that the quadratic model is capable of explaining the overtwisting as a result of coupling between modes of deformation and overstretching as a result of shear instability.
机译：对单个DNA分子的拉伸实验表明，与预期相反，DNA在拉伸时会上风，并且在较大的力下会转变为过度拉伸的形式，这种形式由力-位移图上的平台指示。据信这些作用是DNA弹性反应​​非线性的结果。我们使用离散的碱基对水平模型来模拟短DNA分子的行为，同时考虑到DNA的序列依赖性物理特性以及运动学步长参数之间的耦合，但保留了局部弹性能量函数的二次形式。通过构建平衡构型的分叉图并研究对碱基对组合的依赖性，我们表明，二次模型能够解释由于变形模式和剪切不稳定性导致的过度拉伸之间的耦合而导致的过度扭曲。

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