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首页> 外文期刊>International journal of numerical methods for heat & fluid flow >Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model
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Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model

机译：局部热非平衡二温模型对眼科激光手术的数值模拟

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Purpose This paper aims to understand the laser-tissue interaction mechanism during ophthalmic laser surgeries through numerical analysis. The influence of laser parameters and the multipulse technique were investigated. Design/methodology/approach The ocular fundus was simplified as a multilayered homogenous medium model. Afterward, the multilayer Monte Carlo method was used to simulate the propagation and energy deposition of laser light, and a local thermal non-equilibrium two-temperature model was established to simulate the temperature variation of chromophores and surrounding tissue with different laser wavelength. Findings Through the model, the selective heating of chromophore (melanin and blood vessels) was clearly illustrated: 1) neglecting the laser energy absorbance by blood in the traditional model will cause significant errors in temperature calculation; 2) the non-thermal equilibrium heat transfer model was needed to obtain an accurate description of the thermal process when the dimensionless pulse width (tp*) is <10(5). For 532 nm Argon laser, the optimize tp* is around 10(5) and the appropriate energy density is 5 J/cm(2); 3) multipulse technique makes the energy more concentrated within the melanin, thereby reducing the thermal damage in surrounding tissue, with most appropriate pulse number and duty cycle is 10 and 1/10. Originality/value Taking the blood absorption into account, the different temperature variations of melanin/vessels and surrounding tissue caused by the selective photo-thermolysis were simulated successfully. By understanding the mechanism of laser therapy, laser parameters and multipulse technique are suggested to improve the clinical results.
机译：目的本文旨在通过数值分析来了解眼科激光手术中激光与组织的相互作用机理。研究了激光参数和多脉冲技术的影响。设计/方法/方法眼底简化为多层均质介质模型。然后，采用多层蒙特卡罗方法模拟激光的传播和能量沉积，建立了局部热非平衡二温模型，以模拟不同激光波长的生色团和周围组织的温度变化。通过该模型的发现，清楚地说明了生色团（黑色素和血管）的选择性加热：1）在传统模型中忽略血液对激光的能量吸收会导致温度计算的重大误差； 2）当无因次脉冲宽度（tp *）<10（5）时，需要非热平衡传热模型来获得热过程的准确描述。对于532 nm氩激光器，最佳tp *约为10（5），适当的能量密度为5 J / cm（2）； 3）多脉冲技术使能量更集中在黑色素内，从而减少周围组织的热损伤，最合适的脉冲数和占空比分别为10和1/10。创新性/价值考虑到血液吸收，成功模拟了选择性光热解引起的黑色素/血管和周围组织的不同温度变化。通过了解激光治疗的机理，建议采用激光参数和多脉冲技术来改善临床效果。

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