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Terahertz biosensing metamaterial absorber for virus detection based on spoof surface plasmon polaritons

机译:基于欺骗表面等离子体激元极化子的太赫兹生物传感超材料吸收剂用于病毒检测

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摘要

As a promising candidate for rapid and ultrasensitive sensing of biomolecules, terahertzrn(THz) time-domain spectroscopy is widely used in label-free, noncontact,rnnoninvasive, and nondestructive detection. In this article, planar Jerusalem crossrnmetamaterial absorber for different virus detection based on spoof surface plasmonrnpolaritons (SSPPs) in THz band is investigated. Strongly confined SSPPs modesrnare extracted from the absorption spectra of biosensing metamaterial absorber associatedrnwith local field enhancement. Meanwhile, equivalent complex refractivernindex (N) of different virus subtypes and protein concentrations is numericallyrninvestigated for virus detection. Besides, simulated detections for different virusrnsubtypes (different N) are probed with the proposed biosensing metamaterialrnabsorber. Especially for the simulated detections of three representative AvianrnInfluenza viruses (H5N2, H1N1, H9N2), the proposed THz biosensing metamaterialrnabsorber chip performed ultrasensitive sensitivity and high resolution by extractingrnthe shifted resonance frequencies (ΔF) and the changed values at maximumrnabsorptions (ΔA). All these findings show great significance on a rapid real-timernprocedure for diseases diagnosis especially for the contagious and time-sensitiverntarget virus. The proposed ultrasensitive and selective THz metamaterial absorberrnopens up a new way for planar biosensing chip to be developed into practical applicationsrnin THz regime.
机译:太赫兹(THz)时域光谱法是快速,超灵敏地检测生物分子的有希望的候选者,已广泛用于无标记,非接触,非侵入性和无损检测中。本文研究了基于太赫兹带的表面等离子体激元极化子(SSPPs)的用于不同病毒检测的平面耶路撒冷跨金属材料吸收剂。从与局部场增强相关的生物传感超材料吸收体的吸收光谱中提取出强约束的SSPPs模式。同时,数值研究了不同病毒亚型和蛋白质浓度的等效复数折射率(N),以进行病毒检测。此外,利用拟议的生物传感超材料吸纳剂探测了对不同病毒亚型(不同N)的模拟检测。尤其是对于三种代表性禽流感病毒(H5N2,H1N1,H9N2)的模拟检测,拟议的THz生物传感超材料吸波材料芯片通过提取位移的共振频率(ΔF)和最大吸光度的变化值(ΔA)实现了超灵敏性和高分辨率。所有这些发现对快速实时过程进行疾病诊断,特别是对于具有传染性和时效性的靶标病毒具有重要意义。拟议的超灵敏和选择性太赫兹超材料吸收器为将平面生物传感芯片开发到太赫兹领域的实际应用开辟了一条新途径。

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  • 作者单位

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

    Department of Integrated TCM & Western Medicine, Sichuan 81 Rehabilitation Center, Chengdu 611135, China;

    Department of Integrated TCM & Western Medicine, Sichuan 81 Rehabilitation Center, Chengdu 611135, China;

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

    College of Electronic Science and Technology, Shenzhen University, Shenzhen 518060, China;

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

    School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    biosensing; metamaterial absorber; spoof surface plasmon polaritons; terahertz time-domain spectroscopy; virus detection;

    机译:生物传感超材料吸收体欺骗表面等离激元极化子;太赫兹时域光谱病毒检测;

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