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Implementing toxicity testing in the 21st century: challenges and opportunities

机译:在21世纪实施毒性测试:挑战与机遇

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摘要

The publication of the US National Academy of Sciences report Toxicity Testing in the Twenty-First Century: A Vision and a Strategy (TT21C) has led to the development of new scientific techniques to modernise regulatory toxicity testing. From 2009 to 2010, a series of five international symposia were held to examine challenges, opportunities and policy issues associated with TT21C. Seven key themes emerged based on these meetings; that the TT21C vision and strategy: 1) is not self-implementing; 2) demands new toxicology techniques; 3) has a number of scientific knowledge gaps that need to be filled; 4) requires evaluation of the new tests to determine relevance, reliability, validity and regulatory acceptance by government agencies; 5) can be implemented under TSCA and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) as currently written; 6) requires multi-stakeholder input and commitment; 7) should harmonise acceptance of test data and methods on an international level.
机译:美国国家科学院的出版物《二十一世纪的毒性测试:愿景与策略》(TT21C)导致了新的科学技术的发展,以使监管毒性测试现代化。从2009年到2010年,举行了一系列的五次国际研讨会,以探讨与TT21C相关的挑战,机遇和政策问题。在这些会议的基础上出现了七个关键主题。 TT21C的愿景和策略:1)不能自我实现; 2)需要新的毒理学技术; 3)有许多科学知识空白需要填补; 4)要求对新测试进行评估,以确定相关性,可靠性,有效性和监管机构对政府机构的接受程度; 5)可以根据TSCA和目前制定的《联邦杀虫,杀菌和灭鼠法》(FIFRA)实施; 6)需要多方利益相关者的投入和承诺; 7)应该在国际上协调接受测试数据和方法。

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    Department of Environmental Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA;

    McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, 1 Stewart St., Ottawa, Ontario, KIN 6N5, Canada;

    Animal Legal Defense Fund, 170 E. Cotati Avenue, Cotati, California 94931, USA;

    Center for Animal Law Studies, Lewis & Clark Law School, 10015 SW Terwilliger Blvd., Portland, Oregon 97217, USA;

    Center for Animal Law Studies, Lewis & Clark Law School, 10015 SW Terwilliger Blvd., Portland, Oregon 97217, USA;

    Environment PLLC, 1875 Connecticut Avenue NW, 10th Floor, Washington, DC 20009, USA;

    McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, 850 Peter Morand, Ottawa, Ontario, K1G 3Z7, Canada and Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada and Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON KIP 6L5, Canada;

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  • 正文语种 eng
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  • 关键词

    risk assessment; risk management; toxicity pathway; Toxic Substances Control Act; TSCA; environmental agents; REACH; EU Cosmetic act;

    机译:风险评估;风险管理;毒性途径有毒物质控制法;TSCA;环保剂;达到;欧盟化妆品法;

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