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首页> 外文期刊>International Ophthalmology >Is axial length a risk factor for idiopathic macular hole formation?
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Is axial length a risk factor for idiopathic macular hole formation?

机译：轴向长度是特发性黄斑裂孔形成的危险因素吗？

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摘要

Current theories for macular hole formation implicate antero-posterior and tractional forces at the vitreofoveal interface. It is thought that localized perifoveal defects enlarge from centrifugal forces acting about the axis of ocular rotation. If this is true, eyes with longer axial lengths should have an increased incidence of macular holes. The aim of this study was to determine if axial length is a risk factor for macular hole development. The study group comprised 40 patients with refractive errors from hyperopia to myopia with stage 3 and 4 idiopathic macular holes. Controls matched for age, gender and spherical equivalent (SE) were used for statistical comparison. Axial length (AL) was analyzed using SPSS 13.0 statistical software and compared using Student’s t test. P 0.05 was considered significant. SE ranged from −8.88 to +3.63 dioptres in the macular hole group and −8.50 to +3.63 in controls. In the macular hole group, mean AL ± standard deviation was 23.62 ± 1.20 mm (21.81–27.51); in controls, 23.09 ± 1.16 mm (21.31–26.58). Univariate analysis showed that higher AL is associated with macular hole formation. The mean difference in AL was 0.531 mm (95 % confidence interval −0.1596 to −0.9024). Two-tailed t test: P 0.006. This study showed that increasing ocular AL is significantly associated with macular holes. Dynamic forces at the macula would be greater in these eyes suggesting this may play a causative role in macular hole formation.
机译：黄斑裂孔形成的最新理论牵涉到玻璃体膜交界面的前后和牵引力。可以认为，围绕眼旋转轴作用的离心力会使局灶性中央凹缺损扩大。如果是这样，则更长的眼轴应增加黄斑裂孔的发生。这项研究的目的是确定轴向长度是否是黄斑裂孔发展的危险因素。该研究组包括40名患有远视到近视屈光不正的3到4期特发性黄斑裂孔患者。使用匹配年龄，性别和当量球数（SE）的对照进行统计比较。使用SPSS 13.0统计软件分析轴长（AL），并使用Student t检验进行比较。 P <0.05被认为是显着的。在黄斑裂孔组中，SE的屈光度范围为−8.88至+3.63，在对照组中SE的屈光度范围为−8.50至+3.63。黄斑裂孔组的平均AL±标准差为23.62±1.20 mm（21.81–27.51）；在控件中为23.09±1.16毫米（21.31–26.58）。单因素分析表明，较高的AL与黄斑裂孔形成有关。 AL的平均差异为0.531毫米（95％置信区间-0.1596至-0.9024）。两尾t检验：P <0.006。这项研究表明，眼AL的增加与黄斑裂孔显着相关。在这些眼睛中，黄斑处的动力更大，表明这可能在黄斑裂孔形成中起一定作用。

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  • 来源
    《International Ophthalmology》 |2012年第4期|p.393-396|共4页
  • 作者

    A. J. Singh; M. M. K. Muqit; W. H. Woon;

  • 作者单位

    Department of Ophthalmology, The General Infirmary at Leeds, Clarendon Wing, Belmont Grove, Leeds, LS2 9NS, UK;

    Department of Ophthalmology, The General Infirmary at Leeds, Clarendon Wing, Belmont Grove, Leeds, LS2 9NS, UK;

    Department of Ophthalmology, The General Infirmary at Leeds, Clarendon Wing, Belmont Grove, Leeds, LS2 9NS, UK;

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  • 正文语种 eng
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  • 关键词

    Axial length; Macular hole; Risk factor;

    机译：轴长;黄斑孔;风险因子;

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