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首页> 外文期刊>journal of biomedical optics >In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin
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In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin

机译：人体皮肤皮肤微血管的体内功能光声显微镜

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Microcirculation is an important component of the cardiovascular system and can be used to assessnsystemic cardiovascular health. Numerous studies have investigated cutaneous microcirculation as an indicator ofncardiovascular related diseases. Such research has shown promising results; however, there are many limitationsnregarding the employed measurement techniques, such as poor depth and spatial resolution and measurementnversatility. Here we show the results of functional cutaneous microvascular experiments measured with photoacousticnmicroscopy, which provides high spatial resolution and multiparameter measurements. In a set ofnexperiments, microvascular networks located in the palms of volunteers were perturbed by periodic ischemicnevents, and the subsequent hemodynamic response to the stimulus was recorded. Results indicate that duringnperiods of arterial occlusion, the relative oxygen saturation of the capillary vessels decreased below resting levels,nand temporarily increased above resting levels immediately following the occlusion. Furthermore, a hyperemicnreaction to the occlusions was measured, and the observation agreed well with similar measurements using morenconventional imaging techniques. Due to its exceptional capability to functionally image vascular networks withnhigh spatial resolution, photoacoustic microscopy could be a beneficial biomedical tool to assess microvascularnfunctioning and applied to patients with diseases that affect cardiovascular health. C u0002 2011 Society of Photo-OpticalnInstrumentation Engineers.
机译：微循环是心血管系统的重要组成部分，可用于评估系统性心血管健康。许多研究已经研究了皮肤微循环作为心血管相关疾病的指标。这样的研究显示出令人鼓舞的结果；但是，所采用的测量技术存在很多局限性，例如深度和空间分辨率差以及测量通用性差。在这里，我们显示了使用光声显微镜测量的功能性皮肤微血管实验的结果，该实验提供了高空间分辨率和多参数测量。在一组实验中，位于志愿者手掌的微血管网络受到周期性缺血事件的干扰，并记录了随后对该刺激的血液动力学反应。结果表明，在动脉闭塞期间，毛细血管的相对氧饱和度下降到低于静息水平，并且在阻塞后立即升高到静息水平以上。此外，测量了对闭塞的过度反应，并且观察结果与使用常规成像技术进行的类似测量非常吻合。由于其以高空间分辨率对血管网络进行功能成像的出色能力，光声显微镜可以成为评估微血管功能的有益生物医学工具，并应用于患有影响心血管健康的疾病的患者。 C u0002 2011光电仪器工程师学会。

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