Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors

Andrés Pizzorno; Xavier Bouhy; Yacine Abed

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Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors

机译：抗神经氨酸酶抑制剂的重组大流行性流感A（H1N1）病毒的产生和鉴定

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Background. Neuraminidase inhibitors (NAIs) play a key role in the management of influenza epidemics and pandemics. Given the novel pandemic influenza A(H1N1) (pH1N1) virus and the restricted number of approved anti-influenza drugs, evaluation of potential drug-resistant variants is of high priority.

机译：背景。神经氨酸酶抑制剂（NAIs）在流感流行和大流行的管理中起关键作用。考虑到新型的大流行性甲型H1N1（pH1N1）流感病毒和批准的抗流感药物数量有限，评估潜在的耐药变异体成为当务之急。

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《Journal of Infectious Diseases》 |2011年第1期|p.25-31|共7页
作者
Andrés Pizzorno; Xavier Bouhy; Yacine Abed;
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Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, Québec, Canada;

Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, Québec, Canada;

Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, Québec, Canada;

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1. Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors. [J] . Pizzorno A, Bouhy X, Abed Y, The Journal of Infectious Diseases . 2011,第1期

机译：对神经氨酸酶抑制剂具有抗性的重组大流行性甲型H1N1流感病毒的产生和鉴定。
2. Characterization of neuraminidase inhibitor-resistant influenza A(H1N1)pdm09 viruses isolated in four seasons during pandemic and post-pandemic periods in Japan [J] . TakashitaE., FujisakiS., KishidaN., Influenza and other respiratory viruses. . 2013,第6期

机译：在日本大流行和大流行后的四个季节中分离到的对神经氨酸酶抑制剂具有抗药性的甲型H1N1）pdm09流感病毒的特征
3. Characterization of neuraminidase inhibitor‐resistant influenza A(H1N1)pdm09 viruses isolated in four seasons during pandemic and post‐pandemic periods in Japan [J] . Emi Takashita, Hong Xu, Masaki Imai, Influenza and other respiratory viruses. . 2013,第6期

机译：在日本大流行和大流行后的四个季节中分离到的对神经氨酸酶抑制剂具有抗药性的A（H1N1）pdm09流感病毒的特征
4. Simulated Docking of Zanamivir with the 2009 Pandemic Strain Influenza A/H1N1 Neuraminidase Active Site [C] . Jack K. Horner International Conference on Bioinformatics and Computational Biology . 2012

机译：Zanamivir的模拟对接与2009大流行菌民流感A / H1N1神经氨酸活性位点
5. The Molecular Basis of Fitness and Transmissibility of Neuraminidase Inhibitor Resistant Influenza A Viruses [D] . Duan, Susu 2012

机译：抗神经氨酸酶抑制剂的甲型流感病毒适应性和传播性的分子基础
6. Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors [O] . Andrés Pizzorno, Xavier Bouhy, Yacine Abed, -1

机译：抗神经氨酸酶抑制剂的重组大流行性流感A（H1N1）病毒的产生和鉴定
7. Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors [O] . Pizzorno, Andrés, Bouhy, Xavier, Abed, Yacine, 2011

机译：抗神经氨酸酶抑制剂的重组大流行性流感A（H1N1）病毒的产生和鉴定

Generation and Characterization of Recombinant Pandemic Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors

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