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首页> 外文期刊>Journal of Infectious Diseases >Endogenous IL-13 Plays a Crucial Role in Liver Granuloma Maturation During Leishmania donovani Infection, Independent of IL-4Rα–Responsive Macrophages and Neutrophils
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Endogenous IL-13 Plays a Crucial Role in Liver Granuloma Maturation During Leishmania donovani Infection, Independent of IL-4Rα–Responsive Macrophages and Neutrophils

机译：内源性IL-13在多发性利什曼原虫感染期间在肝肉芽肿成熟中起关键作用，独立于IL-4Rα-反应性巨噬细胞和中性粒细胞

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摘要

Previous studies comparing interleukin 4 receptor α (IL-4Rα)-/- and interleukin 4 (IL-4)-/- BALB/c mice have indicated that interleukin 13 (IL-13), whose receptor shares the IL-4Rα subunit with IL-4, plays a protective role during visceral leishmaniasis. We demonstrate that IL-13-/- BALB/c mice were less able to control hepatic growth of Leishmania donovani compared with wild-type mice. This correlated with significantly retarded granuloma maturation in IL-13-/- mice, defective interferon γ (IFN-γ) production, and elevated IL-4 and interleukin 10 (IL-10) levels. L. donovani–infected IL-13-/- mice also responded poorly to sodium stibogluconate-mediated chemotherapy compared with wild-type BALB/c mice. Because murine lymphocytes do not have IL-13 receptors, we examined the ability of macrophageeutrophil-specific IL-4Rα-/- mice to control primary infection with L. donovani and to respond to chemotherapy. Macrophageeutrophil-specific IL-4Rα-/- mice were as resistant to leishmaniasis as wild-type mice, and chemotherapy retained its efficacy. Consequently, in L. donovani infected BALB/c mice, IL-13 promotes hepatic granuloma formation and controls parasite burdens independently of direct effects on macrophageseutrophils.
机译：先前比较白介素4受体α（IL-4Rα）-/-和白介素4（IL-4）-/- BALB / c小鼠的研究表明白介素13（ IL-13，其受体与IL-4共享IL-4Rα亚基，在内脏利什曼病中起保护作用。我们证明，与野生型小鼠相比，IL-13 -//- BALB / c小鼠不能控制多形利什曼原虫的肝生长。这与IL-13 -/-小鼠中肉芽肿成熟明显延迟，干扰素γ（IFN-γ）产生缺陷以及IL-4和白介素10（IL-10）水平升高有关。与野生型BALB / c小鼠相比，感染多巴尼酵母的IL-13 -/-小鼠对stibogluconate介导的化学疗法的反应也较差。因为鼠类淋巴细胞不具有IL-13受体，所以我们检查了巨噬细胞/嗜中性白细胞特异性IL-4Rα-/-小鼠控制原发性多巴氏乳杆菌感染并对化学疗法作出反应的能力。巨噬细胞/中性粒细胞特异性IL-4Rα-/-小鼠对利什曼病的抵抗力与野生型小鼠相同，化疗仍保持了其功效。因此，在感染多巴尼酵母的BALB / c小鼠中，IL-13促进肝肉芽肿的形成并控制寄生虫负担，而与对巨噬细胞/嗜中性粒细胞的直接作用无关。

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    《Journal of Infectious Diseases》 |2011年第1期|p.36-43|共8页
  • 作者

    Emma McFarlane; Katharine C. Carter; Andrew N. McKenzie; Paul M. Kaye; Frank Brombacher;

  • 作者单位

    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow;

    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow;

    Medical Research Council Laboratory of Molecular Biology, Cambridge;

    Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, United Kingdom;

    International Centre for Genetic Engineering and Biotechnology (ICGEB) and Institute of Infectious Diseases and Molecular Medicine, Health Science Faculty, University of Cape Town, South Africa;

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