CD14 Impairs Host Defense against Gram-Negative Sepsis Caused by Burkholderia pseudomallei in Mice

W. Joost Wiersinga12 Alex F. de Vos12 Catharina W. Wieland12 Masja Leendertse12 Joris J. T. H. Roelofs3 and Tom van der Poll12

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CD14 Impairs Host Defense against Gram-Negative Sepsis Caused by Burkholderia pseudomallei in Mice

机译：CD14损害宿主抵抗小鼠假拟南伯克氏菌引起的革兰氏阴性败血症的能力

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Background. CD14 is a pattern-recognition receptor that can facilitate the presentation of bacterial components to either Toll-like receptor 2 (TLR2) or TLR4. We have recently shown that during melioidosis, a severe infection caused by the gram-negative bacterium Burkholderia pseudomallei, TLR2 but not TLR4 impacts the immune response of the intact host in vivo.

机译：背景。 CD14是一种模式识别受体，可以促进细菌成分呈递给Toll样受体2（TLR2）或TLR4。我们最近显示，在类鼻oid病期间，由革兰氏阴性细菌假小种伯克霍尔德氏菌TLR2引起的严重感染，而不是TLR4会影响完整宿主体内的免疫反应。

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《Journal of Infectious Diseases》 |2008年第9期|p.1388-1397|共10页
作者
W. Joost Wiersinga12 Alex F. de Vos12 Catharina W. Wieland12 Masja Leendertse12 Joris J. T. H. Roelofs3 and Tom van der Poll12;
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1 Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, the Netherlands 2 Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands 3 Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands;

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1. CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice. [J] . Wiersinga WJ, de-Vos AF, Wieland CW, The Journal of Infectious Diseases . 2008,第9期

机译：CD14损害宿主抵抗小鼠假性伯克霍尔德氏菌引起的革兰氏阴性败血症的防御能力。
2. Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis) [J] . Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, PLOS Neglected Tropical Diseases . 2010,第8期

机译：骨桥蛋白在由假伯克霍尔德氏菌（类痔病）引起的革兰氏阴性败血症确立的过程中损害宿主防御
3. Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis) [J] . Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, PLOS Neglected Tropical Diseases . 2010,第8期

机译：骨桥蛋白在由假伯克霍尔德氏菌（类痔病）引起的革兰氏阴性败血症确立的过程中损害宿主防御
4. Gold nanoparticles caused learning impairment in mice [C] . Yu-Shiun Chen, Yao-Ching Hung, Ian Liau, Nanotechnology 2009 : Technical proceedings . 2009

机译：金纳米颗粒导致小鼠学习障碍
5. Evaluation of innate and adaptive immune responses to a Burkholderia pseudomallei outer membrane vesicle vaccine in mice and non-human primates [D] . Petersen, Hailey 2015

机译：评价小鼠和非人类灵长类动物对伯克霍尔德菌假苹果外膜囊泡疫苗的先天性和适应性免疫反应
6. Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis) [O] . Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, 2010

机译：骨桥蛋白在拟南芥（伯克霍尔德氏菌）（乳突病）引起的革兰氏阴性败血症确立期间损害宿主防御
7. CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice [O] . Wiersinga, W. Joost, de Vos, Alex F., Wieland, Catharina W., 2008

机译：CD14损害宿主抵抗小鼠假阳性伯克霍尔德氏菌引起的革兰氏阴性败血症的能力
8. Characterization Of Pathogenesis Of And Immune Response To Burkholderia Pseudomallei K9243 Using Both Inhalational And Intraperitoneal Infection Models In BALB/c and C57BL/6 Mice. [R] . Cote, C. K., Bearss, J. J., Hunter, M., 2017

机译：在BaLB / c和C57BL / 6小鼠中使用吸入和腹膜内感染模型表征Burkholderia pseudomallei K9243的发病机制和免疫应答。

CD14 Impairs Host Defense against Gram-Negative Sepsis Caused by Burkholderia pseudomallei in Mice

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