Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor γ Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction

Patrick W. G. Mallon12a Rebecca Sedwell1 Gary Rogers4a David Nolan5 Patrick Unemori1a Jennifer Hoy6 Katherine Samaras3 Anthony Kelleher12 Sean Emery1 David A. Cooper12 Andrew Carr2 and Rosey Investigatorsb

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Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor γ Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction

机译：罗格列酮对人脂肪组织中过氧化物酶体增殖物激活的受体γ基因表达的影响受抗逆转录病毒药物诱导的线粒体功能障碍的限制

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Background. Treatment of human immunodeficiency virus (HIV)-1 with thymidine-analogue nucleoside reverse-transcriptase inhibitors (tNRTIs) causes lipoatrophy, mitochondrial toxicity, and lower adipose tissue expression of peroxisome proliferator-activated receptor γ (PPARγ [PPARG gene]) . Rosiglitazone (RSG), a PPARγ agonist, improves congenital lipoatrophy but not HIV lipoatrophy.

机译：背景。用胸苷类似物核苷逆转录酶抑制剂（tNRTIs）治疗人免疫缺陷病毒（HIV）-1会导致脂肪萎缩，线粒体毒性和过氧化物酶体增殖物激活受体γ（PPARγ[PPARG基因]）的脂肪组织表达降低。罗格列酮（RSG）是PPARγ激动剂，可改善先天性脂肪萎缩，但不能改善HIV脂肪萎缩。

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《Journal of Infectious Diseases》 |2008年第12期|p.1794-1803|共10页
作者
Patrick W. G. Mallon12a Rebecca Sedwell1 Gary Rogers4a David Nolan5 Patrick Unemori1a Jennifer Hoy6 Katherine Samaras3 Anthony Kelleher12 Sean Emery1 David A. Cooper12 Andrew Carr2 and Rosey Investigatorsb;
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1National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia 2St. Vincent's Hospital, Sydney, Australia 3Garvan Institute of Medical Research, Sydney, Australia 4Department of General Practice, University of Adelaide, Perth, Australia 5Royal Perth Hospital, Perth, Australia 6Alfred Hospital and Monash University, Melbourne, Australia;

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1. Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial dysfunction. [J] . Mallon PW, Sedwell R, Rogers G, The Journal of Infectious Diseases . 2008,第12期

机译：罗格列酮对人脂肪组织中过氧化物酶体增殖物激活的受体γ基因表达的影响受到抗逆转录病毒药物诱导的线粒体功能障碍的限制。
2. Rosiglitazone increases the expression of peroxisome proliferator-activated receptor-gamma target genes in adipose tissue, liver, and skeletal muscle in the sheep fetus in late gestation. [J] . Muhlhausler BS, Morrison JL, McMillen IC Endocrinology . 2009,第9期

机译：罗格列酮可增加妊娠后期绵羊胎儿脂肪组织，肝脏和骨骼肌中过氧化物酶体增殖物激活的受体-γ靶基因的表达。
3. Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. [J] . Meritxell Rosell, Elayne Hondares, Sadahiko Iwamoto, Endocrinology . 2012,第3期

机译：过氧化物酶体增殖物激活受体-α和-γ，以及cAMP介导的途径，控制着棕色脂肪组织中视黄醇结合蛋白4基因的表达。
4. Peroxisome proliferator-activated receptor gamma-insights from human genetics [C] . International Symposium on Atherosclerosis . 2004

机译：来自人类遗传学的过氧化物激素增殖物激活的受体γ-见解
5. The effect of conjugated linoleic acid (CLA) isomers on leptin, adiponectin and peroxisome proliferator-activated receptor (PPAR) expression and their influence on porcine smooth muscle cells. [D] . Zirk, Melissa Michelle. 2005

机译：共轭亚油酸（CLA）异构体对瘦素，脂联素和过氧化物酶体增殖物激活受体（PPAR）表达的影响及其对猪平滑肌细胞的影响。
6. Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α [O] . Rosario Pardo, Natàlia Enguix, Jaime Lasheras, 2011

机译：罗格列酮诱导的白色脂肪组织中的线粒体生物发生与过氧化物酶体增殖物激活受体γCoactivator-1α无关。
7. Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial dysfunction [O] . Mallon, P., Sedwell, R., Rogers, G., 2008

机译：罗格列酮对人体脂肪组织中过氧化物酶体增殖物激活受体γ基因表达的影响受到抗逆转录病毒药物诱导的线粒体功能障碍的限制

Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor γ Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction

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