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首页> 外文期刊>Japanese journal of applied physics >Extracellular Matrix Patterning for Cell Alignment by Atmospheric Pressure Plasma Jets
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Extracellular Matrix Patterning for Cell Alignment by Atmospheric Pressure Plasma Jets

机译:通过大气压等离子射流进行细胞排列的细胞外基质图案

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摘要

Low-temperature atmospheric-pressure plasma (APP) jets and a metal stencil mask have been used for the patterning of fibronectins deposited on a silicon (Si) wafer. Fibronectins typically constitute the extracellular matrix (ECM) and a micro-patterned ECM may be used for arranging living cells in a desired pattern on the substrate surface. Such a technique can be used for the fabrication of cell chips. In this study, patterning of 100-μm-wide lines of fibronectin layers has been demonstrated. Desorption of fibronectins from the surface by plasma application has been confirmed by atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FT-IR).
机译:低温大气压等离子体(APP)射流和金属模板掩膜已用于对沉积在硅(Si)晶圆上的纤连蛋白进行构图。纤连蛋白通常构成细胞外基质(ECM),并且可以使用微图案化的ECM将活细胞以所需的图案排列在基质表面上。这样的技术可以用于电池芯片的制造。在这项研究中,已经证明了100μm宽的纤连蛋白层线的图案。原子力显微镜(AFM)和傅里叶变换红外光谱(FT-IR)证实了血浆中纤连蛋白的表面脱附。

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  • 来源
    《Japanese journal of applied physics》 |2012年第3issue1期|p.036201.1-036201.7|共7页
  • 作者单位

    Center for Atomic and Molecular Technologies, Osaka University, Suita, Osaka 565-0871, Japan;

    Division of Neuroscience, Department of Developmental Biology and Neurosciences, Tohoku University, Sendai 980-8577, Japan;

    Department of Structural Molecular Science, The Graduate University for Advanced Studies, Okazaki, Aichi 444-8585, Japan;

    Electronics-Inspired Interdisciplinary Research Institute, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan;

    Center for Atomic and Molecular Technologies, Osaka University, Suita, Osaka 565-0871, Japan;

    FIRST Research Center for Innovative Nanobiodevice, Nagoya University, Nagoya 464-8603, Japan;

    Center for Atomic and Molecular Technologies, Osaka University, Suita, Osaka 565-0871, Japan;

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