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首页> 外文期刊>Japanese journal of applied physics >Human Umbilical Vein Endothelial Cell Interaction with Fluorine-Incorporated Amorphous Carbon Films
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Human Umbilical Vein Endothelial Cell Interaction with Fluorine-Incorporated Amorphous Carbon Films

机译：人脐静脉内皮细胞与氟结合非晶碳膜的相互作用。

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摘要

A major clinical concern in coronary intervention for cardiovascular disease is late stent thrombosis after the implantation of drug eluting stents (DES). DES widely used in clinical settings currently utilize polymer coatings, which can induce persistent arterial wall inflammation and delayed vascular healing, resulting in impaired endothelialization. We examined the viability of human umbilical vein endothelial cells (HUVECs) for fluorine-incorporated amorphous carbon (a-C:H:F) coatings, which are known to be anti-thrombogenic. a-C:H:F and a-C:H were synthesized on the tissue culture dishes using radio frequency plasma enhanced chemical vapor deposition by varying the ratio of hexafluoroethane and acetylene. HUVECs were seeded on coated dishes for 6 days. The results indicate that the a-C:H:F surface does not disturb HUVEC proliferation in 6 days of culture and is promising for stent materials that allows the preservation of endothelialization, even if the fluorine concentration of a-C:H surface affects the early adhesion of endothelial cells.
机译：冠状动脉介入治疗心血管疾病的主要临床问题是药物洗脱支架（DES）植入后的晚期支架血栓形成。目前在临床环境中广泛使用的DES使用聚合物涂层，该涂层可引起持续的动脉壁炎症和延迟的血管愈合，从而导致内皮化受损。我们检查了人类脐静脉内皮细胞（HUVEC）对于掺氟的无定形碳（a-C：H：F）涂层的可行性，已知该涂层具有抗血栓形成作用。通过改变六氟乙烷和乙炔的比例，使用射频等离子体增强化学气相沉积法在组织培养皿上合成了a-C：H：F和a-C：H。将HUVEC接种在包被的皿上6天。结果表明，aC：H：F表面在培养6天后不会干扰HUVEC的增殖，即使在aC：H表面的氟浓度影响内皮的早期黏附的情况下，也有望用于保留内皮化的支架材料。细胞。

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  • 来源
    《Japanese journal of applied physics》 |2012年第9issue1期|p.090129.1-090129.7|共7页
  • 作者

    Yukihiro Yoshimoto; Terumitsu Hasebe; So Nagashima; Aki Kamijo; Tatsuyuki Nakatani; Takuji Yamagami; Noriko Kitamura; Tomoya Kitagawa; Atsushi Hotta; Koki Takahashi; Tetsuya Suzuki;

  • 作者单位

    Keio University, Yokohama 223-8522, Japan;

    Keio University, Yokohama 223-8522, Japan,Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan;

    Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea;

    Yokohama City University Hospital, Yokohama 236-0004, Japan;

    Toyo Advanced Technologies Co., Ltd., Hiroshima 734-8501, Japan;

    Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan;

    Toho University Sakura Medical Center, Sakura, Chiba 285-8741, Japan;

    Keio University, Yokohama 223-8522, Japan;

    Keio University, Yokohama 223-8522, Japan;

    The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan;

    Keio University, Yokohama 223-8522, Japan;

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