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首页> 外文期刊>Japanese journal of applied physics >Magnetically maneuverable three-dimensional digital microfluidic manipulation of magnetic droplets for biochemical applications
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Magnetically maneuverable three-dimensional digital microfluidic manipulation of magnetic droplets for biochemical applications

机译：磁性可动性的三维数字微流体操纵生物化学应用的磁液滴

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摘要

We propose a three-dimensional (3D) manipulation strategy of magnetic droplets by maneuvering magnetic fields for biochemical applications. To ascertain the feasibility of the 3D manipulation of magnetic droplets, we examine the horizontal and vertical transport of the droplets by the handling of a permanent magnet. The maximum magnet speed (similar to 35 mm s(-1)) that allows for stable droplet transport without any extraction of magnetic particles can be determined through magnetic droplet rotation tests. Additionally, particle extraction from magnetic droplets can be facilitated by introducing a chemically modified surface energy trap. Finally, to demonstrate the applicability of the proposed 3D manipulation strategy to biochemical applications, we examine the transporting and merging of two magnetic droplets containing chemical reactants and subsequent particle extraction from the reacted droplet. The employment of the magnetically steerable 3D manipulation strategy can provide utility and flexibility in the development of 3D digital microfluidics platforms for myriad biochemical (or biomedical) applications.
机译：我们提出了一种通过用于生化应用的磁场来提出磁液滴的三维（3D）操纵策略。为了确定磁液滴的3D操纵的可行性，我们通过处理永磁体来检查液滴的水平和垂直传输。通过磁性液滴旋转试验确定允许稳定液滴传输的最大磁速（类似于35mm S（-1）），其无需任何磁性颗粒。另外，通过引入化学改性的表面能阱，可以促进来自磁液滴的颗粒提取。最后，为了证明所提出的3D操纵策略对生物化学应用的适用性，我们研究了含有化学反应物的两个磁液滴的运输和合并，并从反应液滴中提取后续颗粒萃取。磁力可操纵的3D操纵策略的就业可以为多数生物化学（或生物医学）应用的3D数字微流体平台的开发提供效用和灵活性。

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