Vitreous Fluid Levels of β-Amyloid(1–42)</sub> and Tau in Patients with Retinal Diseases

Shinji Yoneda; Hideaki Hara; Akira Hirata; Mikiko Fukushima; Yasuya Inomata; Hidenobu Tanihara

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Vitreous Fluid Levels of β-Amyloid(1–42) and Tau in Patients with Retinal Diseases

机译：视网膜疾病患者β-淀粉样蛋白（1-42）和Tau的玻璃体液水平

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摘要

A decrease in β-amyloid1–42 (Aβ42) and an increase in tau in the cerebrospinal fluid are reported to be characteristic phenomena in Alzheimer’s disease patients. To test the idea that Aβ42 and tau contribute to the development of retinal diseases, we measured Aβ42 and tau concentrations in the vitreous fluid from patients with macular hole (n = 13), diabetic retinopathy (n = 15), or glaucoma concurrent with other ocular diseases (n = 8).

机译：据报道，β-淀粉样蛋白1-42（Aβ42）的减少和脑脊液中tau的增加是阿尔茨海默氏病患者的特征性现象。为了检验Aβ42和tau有助于视网膜疾病发展的观点，我们测量了黄斑裂孔（n = 13），糖尿病性视网膜病变（n = 15）或青光眼并发其他疾病的患者的玻璃体液中Aβ42和tau的浓度眼部疾病（n = 8）。

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来源
《Japanese Journal of Ophthalmology》 |2005年第2期|106-108|共3页
作者
Shinji Yoneda; Hideaki Hara; Akira Hirata; Mikiko Fukushima; Yasuya Inomata; Hidenobu Tanihara;
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作者单位

Research and Development Center Santen Pharmaceutical Company Ltd.;

Department of Biofunctional Molecules Gifu Pharmaceutical University;

Department of Ophthalmology and Visual Science Kumamoto University Graduate School of Medical Sciences;

Department of Ophthalmology and Visual Science Kumamoto University Graduate School of Medical Sciences;

Department of Ophthalmology and Visual Science Kumamoto University Graduate School of Medical Sciences;

Department of Ophthalmology and Visual Science Kumamoto University Graduate School of Medical Sciences;

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正文语种 eng
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β-amyloid; diabetic retinopathy; glaucoma; tau; vitreous fluid;

机译：β-淀粉样蛋白;糖尿病性视网膜病变;青光眼;tau;玻璃体液;

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专利

1. Vitreous fluid levels of beta-amyloid((1-42)) and tau in patients with retinal diseases. [J] . Yoneda S, Hara H, Hirata A, Japanese Journal of Ophthalmology . 2005,第2期

机译：视网膜疾病患者的β-淀粉样蛋白（（1-42））和tau的玻璃体液水平。
2. Association of cerebrospinal fluid β-amyloid 1-42, t-tau, p-tau 181, and α-synuclein levels with clinical features of drug-naive patients with early parkinson disease [J] . KangJ.-H., IrwinD.J., Chen-PlotkinA.S., JAMA neurology . 2013,第10期

机译：脑脊液β-淀粉样蛋白1-42，t-tau，p-tau 181和α-突触核蛋白水平与单纯性帕金森病初治患者的临床特征相关
3. Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. [J] . Sunderland T, Linker G, Mirza N, JAMA: the Journal of the American Medical Association . 2003,第16期

机译：阿尔茨海默氏病患者的脑脊液中β-淀粉样蛋白1-42降低且tau水平升高。
4. Levels of Interleukin-1β in Gingival Crevicular Fluid in Patients with Coronary Heart Disease and Its Relationship to Periodontal Status [C] . Putri Lenggogeny, Sri Lelyati C. Masulili, Fatimah M Tadjoedin, International Symposium of Biomedical Engineering . 2017

机译：冠心病患者牙龈颈液中白细胞介素-1β的水平及其与牙周地位的关系
5. Developing the Next Generation Rapid Diagnostic Microfluidic Devices for Measuring the Protein Levels in Multiple Myeloma Patients for Early Detection of Disease Re-Appearance [D] . Labovitis, Nicolas. 2021

机译：开发下一代快速诊断微流体装置，用于测量多发性骨髓瘤患者的蛋白质水平，以早期检测疾病重新出现
6. Association of Cerebrospinal Fluid β-Amyloid 1-42 T-tau P-tau181 and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease [O] . Ju-Hee Kang, David J. Irwin, Alice S. Chen-Plotkin, -1

机译：脑脊液β-淀粉样蛋白1-42T-tauP-tau181和α-突触核蛋白水平与单纯性帕金森病患者的临床特征相关
7. Association of cerebrospinal fluid β-amyloid 1-42, t-tau, p-tau ₁₈₁, and α-synuclein levels with clinical features of drug-naive patients with early parkinson disease [O] . Kang, Ju-Hee, Irwin, David J, Marek, Kenneth, 2013

机译：脑脊液β-淀粉样蛋白1-42，t-tau，p-tau and和α-突触核蛋白水平与单纯性帕金森病初治患者的临床特征相关

Vitreous Fluid Levels of β-Amyloid(1–42) and Tau in Patients with Retinal Diseases

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