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首页> 外文期刊>Journal of the American Chemical Society >Dual Functional Polyelectrolyte Multilayer Coatings for Implants: Permanent Microbicidal Base with Controlled Release of Therapeutic Agents
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Dual Functional Polyelectrolyte Multilayer Coatings for Implants: Permanent Microbicidal Base with Controlled Release of Therapeutic Agents

机译：植入物的双重功能聚电解质多层涂层：永久性杀菌基团，可控制释放治疗剂

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摘要

Here we present a new bifunctional layer-by-layer (LbL) construct made by combining a permanent microbicidal polyelectrolyte multilayered (PEM) base film with a hydrolytically degradable PEM top film that offers controlled and localized delivery of therapeutics. Two degradable film architectures are presented: (1) bolus release of an antibiotic (gentamicin) to eradicate initial infection at the implant site, or (2) sustained delivery of an anti-inflammatory drug (diclofenac) to cope with inflammation at the site of implantation due to tissue injury. Each degradable film was built on top of a permanent base film that imparts the implantable device surface with microbicidal functionality that prevents the formation of biofilms. Controlled-delivery of gentamicin was demonstrated over hours and that of diclofenac over days. Both drugs retained their efficacy upon release. The permanent microbicidal base film was biocompatible with A549 epithelial cancer cells and MC3T3-E1 osteoprogenitor cells, while also preventing bacteria attachment from turbid media for the entire duration of the two weeks studied. The microbicidal base film retains its functionality after the biodegradable films have completely degraded. The versatility of these PEM films and their ability to prevent biofilm formation make them attractive as coatings for implantable devices.
机译：在这里，我们介绍了一种新的双功能逐层（LbL）结构，该结构是通过将永久性杀菌聚电解质多层（PEM）基膜与可水解降解的PEM顶膜相结合而制成的，该膜可提供治疗药物的受控和局部递送。提出了两种可降解的膜结构：（1）推注释放抗生素（庆大霉素）以根除植入部位的初始感染，或（2）持续输送抗炎药（双氯芬酸）以应对植入部位的炎症。因组织损伤而植入。每个可降解膜都建在永久性基膜的顶部，该基膜为可植入设备的表面提供了防止生物膜形成的杀菌功能。庆大霉素的控释量超过数小时，双氯芬酸的控释量超过数天。两种药物在释放时均保持其功效。永久性杀微生物基膜与A549上皮癌细胞和MC3T3-E1骨祖细胞具有生物相容性，同时在整个研究的两周内，还可以防止细菌从混浊介质中附着。在可生物降解膜完全降解之后，杀菌基膜保留其功能。这些PEM膜的多功能性以及它们防止生物膜形成的能力使它们作为可植入设备的涂层具有吸引力。

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  • 来源
    《Journal of the American Chemical Society》 |2010年第50期|p.17840-17848|共9页
  • 作者

    Sze Yinn Wong Renée;

  • 作者单位

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Harvard;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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