Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes

Danilo C. Miguel1 Jenicer K. U. Yokoyama-Yasunaka1 Walter K. Andreoli2 Renato A. Mortara2 and Silvia R. B. Uliana1

首页> 外文期刊>Journal of Antimicrobial Chemotherapy >Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes

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Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes

机译：他莫昔芬有效对抗利什曼原虫并诱导携带利什曼原虫（Leishmania）amazonensis amastigotes的寄生虫液泡快速碱化

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Objectives This study was performed to investigate the activity of tamoxifen, an antioestrogen widely used in the treatment of breast cancer, against Leishmania.

机译：目的进行这项研究以研究他莫昔芬（一种广泛用于治疗乳腺癌的抗雌激素药物）对利什曼原虫的活性。

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《Journal of Antimicrobial Chemotherapy》 |2007年第3期|526-534|共9页
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Danilo C. Miguel1 Jenicer K. U. Yokoyama-Yasunaka1 Walter K. Andreoli2 Renato A. Mortara2 and Silvia R. B. Uliana1;
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Departamento de Parasitologia Instituto de Ciências Biomédicas Universidade de São Paulo São Paulo 05508-900 SP Brazil;

Departamento de Microbiologia Imunologia e Parasitologia Escola Paulista de Medicina Universidade Federal de São Paulo São Paulo 04023-062 SP Brazil;

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1. Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes. [J] . Miguel DC, Yokoyama-Yasunaka JK, Andreoli WK, The Journal of Antimicrobial Chemotherapy . 2007,第3期

机译：他莫昔芬对付利什曼原虫是有效的，并诱导携带利什曼原虫（Leishmania）amazonensis amastigotes的寄生虫液泡快速碱化。
2. H-2M molecules, like MHC class II molecules, are targeted to parasitophorous vacuoles of Leishmania-infected macrophages and internalized by amastigotes of L. amazonensis and L. mexicana. [J] . Antoine JC, Lang T, Prina E, Journal of Cell Science . 1999,第Pta15期

机译：H-2M分子像MHC II类分子一样，被靶向利什曼原虫感染的巨噬细胞的寄生虫空泡，并被亚马逊乳杆菌和墨西哥乳杆菌的弹药所内化。
3. Biogenesis of Leishmania-harbouring parasitophorous vacuoles following phagocytosis of the metacyclic promastigote or amastigote stages of the parasites [J] . Courret N., Frehel C., Gouhier N., Journal of Cell Science . 2002,第11期

机译：利什曼原虫携带的寄生虫液泡的生物发生后，寄生虫的元环前鞭毛体或鞭毛体阶段吞噬。
4. Efficacy of the Photodynamic Antimicrobial Therapy (PACT) with the use of Methylene Blue Associated with the X660nm laser in Leishmania (Leishmania) amazonensis: In Vitro Study [C] . Gustavo M. Pires-Santos, Aparecida M. C. Marques, Elisamara S.S. Alves, Mechanisms for low-light therapy VII . 2012

机译：亚甲蓝与X660nm激光联合应用光动力学抗菌疗法（PACT）在亚马逊利什曼原虫（Leishmania）中的功效：体外研究
5. Differential regulation of dendritic cell migration after Leishmania major and Leishmania amazonensis infection [D] . Soto Ruiz, Victor Raul 2007

机译：大利什曼原虫和亚马逊利什曼原虫感染后树突状细胞迁移的差异调节
6. Fusion between Leishmania amazonensis and Leishmania major Parasitophorous Vacuoles: Live Imaging of Coinfected Macrophages [O] . Fernando Real, Renato A. Mortara, Michel Rabinovitch 2010

机译：亚马逊利什曼原虫和主要利什曼原虫寄生虫卵泡融合：合并感染的巨噬细胞的实时成像。
7. Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes [O] . Danilo C. Miguel, Jenicer K. U. Yokoyama-Yasunaka, Walter K. Andreoli, 2007

机译：Tamoxifen对Leishmania有效，并诱导寄生菌窝藏的快速碱化，含有Leishmania（Leishmania）Amakonensis Amastigotes
8. Receptor-Mediated Phagocytosis and Parasitophorous Vacuole Maturation of Leishmania Amazonensis Promastigotes. [R] . Benjack, J. A. 2001

机译：Leishmania amazonensis promastigotes的受体介导的吞噬作用和parasitophorous Vacuole成熟。

Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes

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