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Spectral Properties of the TGF Pathway

机译:TGF途径的光谱性质

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摘要

The tubuloglomerular feedback (TGF) mechanism regulates the rate of fluid and solute entry into the nephrons, the functional units of the kidney. Experiments in rats have shown that key variables in the TGF pathway may exhibit a regular, sustained oscillation, of frequency ~35 mHz; further experiments have revealed substantial spectral complexity, of unknown etiology, up to 500 mHz, in blood flow through the associated vasculature. We have previously published a simple mathematical model of the TGF pathway that predicts the low-frequency oscillation. Here we report additional analysis of the model that suggests that the spectral complexity in the 50-500 mHz range arises, at least in part, from intrinsic properties of the TGF pathway.
机译:肾小管肾小球反馈(TGF)机制可调节体液和溶质进入肾脏功能单元肾的速度。在大鼠中进行的实验表明,TGF途径中的关键变量可能表现出规则的,持续的振荡,频率约为35 mHz。进一步的实验表明,在通过相关脉管系统的血流中,高达500 mHz的病因学尚不明确,存在相当大的频谱复杂性。我们之前已经发布了预测低频振荡的TGF途径的简单数学模型。在这里,我们报告该模型的其他分析,表明50-500 mHz范围内的频谱复杂性至少部分是由TGF途径的内在特性引起的。

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