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An integrated hollow-core photonic crystal fiber transverse optical trapping system for optical manipulation and detection

机译:用于光学操作和检测的集成空心光子晶体光纤横向光阱系统

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摘要

Optical manipulation, separation, and detection of biological cells have immense potential biomedical applications, for example, in disease detection. In this paper, we present optical manipulation and detection of micron sized fluorescent particles inside hollow-core photonic crystal fiber (HC-PCF) by transverse optical trapping. An optical trapping system is designed where a near-infrared laser light is focused using a microscope objective to create an optical trap across a liquid-filled HC-PCF. The fluorescent microsphere particles trapped in the core of HC-PCF using the laser induced optical force further undergo imaging and fluorescence spectroscopic analysis. It is illustrated that the proposed method can track the particle into a different medium using the optical trap as well. The obtained results indicate that this proposed method has tangible potential for developing HC-PCF based lab-on-a-chip bio/chemical sensors capable of detecting reagents in ultra low sample volumes.
机译:生物细胞的光学操作,分离和检测在例如疾病检测中具有巨大的潜在生物医学应用。在本文中,我们介绍了通过横向光阱对空心光子晶体光纤(HC-PCF)内的微米级荧光粉进行光学处理和检测。设计了一种光阱系统,其中使用显微镜物镜将近红外激光聚焦,从而在充满液体的HC-PCF上形成光阱。利用激光诱导的光力捕获在HC-PCF核心中的荧光微球颗粒进一步经过成像和荧光光谱分析。说明了所提出的方法也可以使用光阱将粒子追踪到不同的介质中。获得的结果表明,该方法具有开发基于HC-PCF的芯片实验室生物/化学传感器的切实潜力,该传感器能够检测超低样品量的试剂。

著录项

  • 来源
    《Journal of Applied Physics》 |2012年第2期|p.023106.1-023106.5|共5页
  • 作者

    V. K. Shinoj; V. M. Murukeshan;

  • 作者单位

    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue,Singapore 639798;

    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue,Singapore 639798;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
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