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Photothermal therapy based on magnetic nanoparticles in cancer

机译：基于癌症磁性纳米粒子的光热疗

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摘要

Photothermal therapy (PTT) is an extensively used kind of cancer treatment based on thermal energy,which has been technically mature relative to other emerging nanotechnologies. Initially,single-phase magnetic nanoparticles (NPs) have been used for PTT due to their excellent biocompatibility and photothermal properties. With the boom of research,various types of composite-phase NPs have been developed to improve the efficiency and broaden the application range of PTT. The synergistic effect of PTT and other therapies have also gradually attracted the attention of researchers in achieving enhanced tumor elimination. However,the intrinsic obstacles of PTT have restricted the widespread clinical application,and the vague pathological mechanisms of PTT have also made it more difficult to promote clinical translation. In this Perspective,the current research progress of PTT including a diversified selection of magnetic NPs prospects toward the clinic,and the potential pathological mechanism will be overviewed. Meanwhile,the potential outlook of open challenges will be discussed for the utility of PTT.
机译：光热疗（PTT）是基于热能的广泛使用的癌症治疗，其在技术上相对于其他新出现的纳米技术成熟。最初，由于其优异的生物相容性和光热性能，已经用于PTT的单相磁性纳米颗粒（NPS）。随着研究的繁荣，已经开发出各种类型的复合阶段NPS来提高效率并拓宽PTT的应用范围。 PTT和其他疗法的协同效应也逐渐引起了研究人员在实现增强的肿瘤消除方面的注意力。然而，PTT的内在障碍限制了广泛的临床应用，PTT的模糊病理机制也使得促进临床翻译更加困难。在这种观点中，PTT的目前的研究进展包括朝向诊所的多样化磁NPS前景，以及潜在的病理机制将被概述。同时，将讨论PTT的效用将讨论潜在的开放挑战观。

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  • 来源
    《Journal of Applied Physics》 |2021年第7期|070902.1-070902.11|共11页
  • 作者

    Shuren Wang; Yanglong Hou;

  • 作者单位

    Beijing Key Laboratory of Magnetoeiectric Materials and Devices School of Materials Science and Engineering Beijing Innovation Centre for Engineering Science and Advanced Technology Peking University Beijing 100871 China;

    Beijing Key Laboratory of Magnetoeiectric Materials and Devices School of Materials Science and Engineering Beijing Innovation Centre for Engineering Science and Advanced Technology Peking University Beijing 100871 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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