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Influence diagnostics for the Weibull-Negative-Binomial regression model with cure rate under latent failure causes

机译:潜在失效原因下具有治愈率的Weibull-Negative-Binomial回归模型的影响诊断

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摘要

In this paper, we propose a flexible cure rate survival model by assuming that the number of competing causes of the event of interest follows the Negative Binomial distribution and the time to event follows a Weibull distribution. Indeed, we introduce the Weibull-Negative-Binomial (WNB) distribution, which can be used in order to model survival data when the hazard rate function is increasing, decreasing and some non-monotonous shaped. Another advantage of the proposed model is that it has some distributions commonly used in lifetime analysis as particular cases. Moreover, the proposed model includes as special cases some of the well-know cure rate models discussed in the literature. We consider a frequentist analysis for parameter estimation of a WNB model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. Finally, the methodology is illustrated on a medical data.
机译:在本文中,我们通过假设感兴趣事件的竞争原因数量服从负二项式分布且事件发生时间服从Weibull分布来提出灵活的治愈率生存模型。确实,我们引入了威布尔-负二项式(WNB)分布,当危险率函数增加,减小并且呈非单调形状时,可用于对生存数据进行建模。提出的模型的另一个优点是,它具有一些寿命分析中常用的分布作为特殊情况。此外,提出的模型包括一些在文献中讨论过的众所周知的治愈率模型作为特殊情况。我们考虑对具有治愈率的WNB模型的参数估计进行频繁分析。然后,我们推导出适当的矩阵,以评估在不同摄动方案下对参数估计值的局部影响,并提出一些进行全局影响分析的方法。最后,在医学数据上说明了该方法。

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