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首页> 外文期刊>Journal of applied statistics >Applying functional data analysis to assess tele-interpersonal psychotherapy's efficacy to reduce depression
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Applying functional data analysis to assess tele-interpersonal psychotherapy's efficacy to reduce depression

机译：应用功能数据分析评估远程人际心理治疗的减少抑郁症的功效

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The use of parametric linear mixed models and generalized linear mixed models to analyze longitudinal data collected during randomized control trials (RCT) is conventional. The application of these methods, however, is restricted due to various assumptions required by these models. When the number of observations per subject is sufficiently large, and individual trajectories are noisy, functional data analysis (FDA) methods serve as an alternative to parametric longitudinal data analysis techniques. However, the use of FDA in RCTs is rare. In this paper, the effectiveness of FDA and linear mixed models (LMMs) was compared by analyzing data from rural persons living with HIV and comorbid depression enrolled in a depression treatment randomized clinical trial. Interactive voice response systems were used for weekly administrations of the 10-item Self-Administered Depression Scale (SADS) over 41 weeks. Functional principal component analysis and functional regression analysis methods detected a statistically significant difference in SADS between telphone-administered interpersonal psychotherapy (tele-IPT) and controls but linear mixed effects model results did not. Additional simulation studies were conducted to compare FDA and LMMs under a different nonlinear trajectory assumption. In this clinical trial with sufficient per subject measured outcomes and individual trajectories that are noisy and nonlinear, we found FDA methods to be a better alternative to LMMs.
机译：使用参数线性混合模型和广义的线性混合模型来分析随机控制试验期间收集的纵向数据（RCT）是常规的。然而，由于这些模型所需的各种假设，这些方法的应用受到限制。当每个受试者的观察数量足够大，并且单独的轨迹是嘈杂的，功能数据分析（FDA）方法用作参数纵向数据分析技术的替代。然而，在RCT中使用FDA是罕见的。本文通过分析来自患有艾滋病毒和共同抑郁症的农村人群的数据进行分析，对抑郁症治疗随机临床试验进行了分析了FDA和线性混合模型（LMMS）的有效性。交互式语音响应系统用于每周10项自我管理抑郁症（SADS）的每周主管部门，超过41周。功能性主成分分析和功能回归分析方法检测到Telphone-施用的人际心理治疗（Tele-IPT）和控制之间的悲伤差异差异，但线性混合效果模型结果没有。进行额外的模拟研究以在不同的非线性轨迹假设下比较FDA和LMM。在这种具有足够的临床试验中，每个受试者测量结果和嘈杂和非线性的个体轨迹，我们发现FDA方法是LMM的更好的替代方法。

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