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首页> 外文期刊>Journal of Asian earth sciences >Lifetime risk of urothelial carcinoma and lung cancer in the arseniasis-endemic area of Northeastern Taiwan
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Lifetime risk of urothelial carcinoma and lung cancer in the arseniasis-endemic area of Northeastern Taiwan

机译：台湾东北部砷病流行区的尿路上皮癌和肺癌的终生风险

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摘要

Arsenic in drinking water has been shown to increase the risk of urothelial carcinoma and lung cancer. However, the lifetime risk of developing urothelial carcinoma and lung cancer caused by exposure to arsenic in drinking water has not been reported. This study aimed to assess the lifetime risk of urothelial carcinoma and lung cancer caused by arsenic exposure from drinking water and cigarette smoking habit for residents living in the arseniasis-endemic area in Northeastern Taiwan. We recruited 8086 residents in 1991-1994 and monitored them for their newly developed types of cancers, identified by computerized linkage with the national cancer registry profile. There were 37 newly diagnosed urothelial carcinoma cases and 223 new lung cancer cases during the follow-up period (until 2007). The lifetime (35-85 years old) cumulative risk of developing urothelial carcinoma from an arsenic concentration in the drinking water of ＜10,10-99, and 100+ μg/L was 0.29%, 1.07% and 3.43%, respectively. The corresponding probabilities were 7.42%, 8.99% and 17.09% for the lifetime risk of developing lung cancer. Cigarette smoking was associated with an increased risk of urothelial carcinoma and lung cancer, showing the hazard ratio (95% confidence interval) of 2.48 (1.27-4.82) and 3.44 (2.00-5.90) after adjusting for the arsenic concentration in drinking water. After adjusting for cigarette smoking, the hazard ratio (95% confidence interval) of developing urothelial carcinoma caused by the arsenic concentration in drinking water of ＜10, 10-99 and 100+ μg/L was 1.0 (the reference group), 2.18 (0.59-8.01), and 8.71 (2.49-30.48), respectively. The corresponding figures were 1.0 (the reference group), 1.14 (0.80-1.61), 1.84 (1.28-2.65) for lung cancer. Synergistic effects on the development of urothelial carcinoma and lung cancer existed between the arsenic exposure level and cigarette smoking. It is suggested that people who have had a high exposure to arsenic in drinking water should stop smoking cigarettes to lower their lifetime risk of urothelial carcinoma and lung cancer.
机译：已显示饮用水中的砷会增加尿路上皮癌和肺癌的风险。然而，尚未有因饮用水中砷暴露而终生发展为尿路上皮癌和肺癌的风险的报道。这项研究旨在评估生活在台湾东北部砷病流行地区的居民因饮水和吸烟习惯中的砷暴露而终生患上皮癌和肺癌的风险。我们在1991-1994年招募了8086名居民，并通过与国家癌症登记系统的计算机链接确定了他们的新型癌症类型，并对其进行了监控。在随访期间（至2007年），新诊断尿路上皮癌病例37例，新肺癌病例223例。饮用水中砷浓度＜10、10-99和100+μg/ L的终生（35-85岁）患尿路上皮癌的累积风险分别为0.29％，1.07％和3.43％。罹患肺癌的终生风险的相应概率分别为7.42％，8.99％和17.09％。吸烟与尿路上皮癌和肺癌的风险增加相关，在调整了饮用水中的砷浓度后，其危害比（95％置信区间）为2.48（1.27-4.82）和3.44（2.00-5.90）。调整吸烟后，饮用水中砷浓度＜10、10-99和100+μg/ L引起的发展性尿路上皮癌的危险比（参考组）为1.0（参考组），2.18（ 0.59-8.01）和8.71（2.49-30.48）。肺癌的相应数字是1.0（参考组），1.14（0.80-1.61），1.84（1.28-2.65）。砷暴露水平与吸烟之间存在着对尿路上皮癌和肺癌发展的协同作用。建议饮用水中砷含量高的人应停止吸烟，以降低其一生中尿路上皮癌和肺癌的风险。

著录项

  • 来源
    《Journal of Asian earth sciences》 |2013年第15期|332-337|共6页
  • 作者

    Tse-Yen Yang; Ling-I Hsu; Hui-Chi Chen; Hung-Yi Chiou; Yu-Mei Hsueh; Meei-Maan Wu; Chi-Ling Chen; Yuan-Hung Wang; Ya-Tang Liao; Chien-Jen Chen;

  • 作者单位

    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan,Genomics Research Center, Academia Sinica, Taipei, Taiwan;

    Genomics Research Center, Academia Sinica, Taipei, Taiwan;

    Genomics Research Center, Academia Sinica, Taipei, Taiwan;

    School of Public Health, Taipei Medical University, Taipei, Taiwan;

    School of Public Health, Taipei Medical University, Taipei, Taiwan;

    School of Public Health, Taipei Medical University, Taipei, Taiwan,Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan;

    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;

    Division of Urology, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan,Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;

    Genomics Research Center, Academia Sinica, Taipei, Taiwan,Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan;

    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan,Genomics Research Center, Academia Sinica, Taipei, Taiwan,Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan,Genomic Research Center, Academia Sinica, No. 128, Section 2, Academia Rd., Nankang, Taipei 11529, Taiwan;

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  • 正文语种 eng
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  • 关键词

    Arsenic; Urothelial carcinoma; Lung cancer; Lifetime risk; Cigarette smoking;

    机译：砷;尿路上皮癌;肺癌;终身风险;吸烟;

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