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首页> 外文期刊>Journal of Autism and Developmental Disorders >Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial
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Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

机译：患有褪黑素与安慰剂的自闭症谱系状况和严重的睡眠问题不适合行为管理策略的儿童：一项随机对照试验

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摘要

Twenty-two children with autism spectrum disorders who had not responded to supported behaviour management strategies for severe dysomnias entered a double blind, randomised, controlled crossover trial involving 3 months of placebo versus 3 months of melatonin to a maximum dose of 10 mg. 17 children completed the study. There were no significant differences between sleep variables at baseline. Melatonin significantly improved sleep latency (by an average of 47 min) and total sleep (by an average of 52 min) compared to placebo, but not number of night wakenings. The side effect profile was low and not significantly different between the two arms.
机译：22名自闭症谱系障碍儿童未对严重的失眠症的支持的行为管理策略做出反应，进入了一项双盲，随机，对照的交叉试验，该试验涉及3个月的安慰剂和3个月的褪黑激素，最大剂量为10 mg。 17名儿童完成了研究。基线时睡眠变量之间无显着差异。与安慰剂相比，褪黑激素可显着改善睡眠潜伏期（平均47分钟）和总睡眠时间（平均52分钟），但不能改善夜间睡眠次数。副作用低，两个手臂之间没有明显差异。

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